Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
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Summary
A new membrane protein topology prediction method, TMHMM, based on a hidden Markov model is described and validated, and it is discovered that proteins with N(in)-C(in) topologies are strongly preferred in all examined organisms, except Caenorhabditis elegans, where the large number of 7TM receptors increases the counts for N(out)-C-in topologies.
- Type
- article
- Published
- 2001-01-19
- Cited by
- 12,791
- References
- 38
- OpenAlex
- https://openalex.org/W2152770371
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15769874
Keywords
Membrane topology, Caenorhabditis elegans, Transmembrane protein, Membrane protein, Network topology
References
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- Molecular cloning of an unusual bicistronic cholecystokinin receptor mRNA expressed in chicken brain: a structural and functional expression study.
- Intramembrane proteolysis by the aspartic protease SPP
- The HMMTOP transmembrane topology prediction server
- Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes.
- Characterization of the nodulation plasmid encoded chemoreceptor gene mcpG from Rhizobium leguminosarum
- etramps, a new Plasmodium falciparum gene family coding for developmentally regulated and highly charged membrane proteins located at the parasite-host cell interface.
- In silico prediction of the peroxisomal proteome in fungi, plants and animals.
- The BON domain: a putative membrane-binding domain.
- Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major.
- Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6.
- Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism.
- A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand
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- The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.
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