IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.

Keywords

NPM1, IDH2, CEBPA, Myeloid leukemia, Medicine

References

• Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases.Robert J. Haselbeck, L. McAlister-Henn — 1993
• Modeling Survival Data: Extending the Cox ModelTerry M. Therneau, Patricia M. Grambsch — 2000
• Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1αShimin Zhao, Yan Lin, Wei Xu — 2009
• Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival AnalysisSunil J Rao — 2003
• Proportional hazards tests and diagnostics based on weighted residualsPatricia M. Grambsch, Terry M. Therneau — 1994
• Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria.Eduard A. Struys, Gajja S. Salomons, Younès Achouri — 2005
• Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not childrenJames Hayden, Michael C. Frühwald, Martin Hasselblatt — 2009
• l-2-Hydroxyglutaric aciduria, a disorder of metabolite repairEmile Van Schaftingen, R. Rzem, Maria Veiga‐da‐Cunha — 2009
• The Use of Denaturing High-Performance Liquid Chromatography (DHPLC) for the Analysis of Genetic Variations: Impact for Diagnostics and PharmacogeneticsFelix W. Frueh, Mario Noyer-Weidner — 2003
• Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity*Xiang Xu, Jingyue Zhao, Zhen Xu — 2004
• The Human PICD Gene Encodes a Cytoplasmic and Peroxisomal NADP+-dependent Isocitrate Dehydrogenase*Brian V. Geisbrecht, Stephen J. Gould — 1999
• Absence of IDH2 codon 172 mutation in common human cancersSang Wook Park, Nak Gyun Chung, Ji Youn Han — 2009
• Probable assignment of soluble isocitrate dehydrogenase (IDH1) to 2q33.3Kouji Narahara, Shunsuke Kimura, Kiyoshi Kikkawa — 2004
• Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family.Anton Nekrutenko, David M. Hillis, John C. Patton — 1998
• Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancersMi Ran Kang, Min Sung Kim, Ji Eun Oh — 2009
• An Integrated Genomic Analysis of Human Glioblastoma MultiformeD. Williams Parsons, Siân Jones, Xiaosong Zhang — 2008
• Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.Richard F. Schlenk, Konstanze Döhner, Jürgen Krauter — 2008
• The subcellular location of isozymes of NADP-isocitrate dehydrogenase in tissues from pig, ox and rat.Gerhard Plaut, Michael N. Cook, Tadashi Aogaichi — 1983
• Role of NADP+‐dependent isocitrate dehydrogenase (NADP+‐ICDH) on cellular defence against oxidative injury by γ‐raysSang‐Hyun Lee, Sang‐Hyun Lee, Seung‐Hee Jo — 2004
• Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndromeTakuya Watanabe, Anne Vital, Sumihito Nobusawa — 2009

Cited by

• IDH1 and IDH2 mutations in myeloid neoplasms – Novel paradigms and clinical implicationsCristina-Elena Albu — 2010
• Leukemia stem cells and microenvironment: biology and therapeutic targeting.Paloma Bilbao Calabuig — 2011
• Impact of molecular prognostic factors in cytogenetically normal acute myeloid leukemia at diagnosis and relapse守 和田 — 2011
• NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.W. J. Rorabaugh — 2011
• Lessons from next-generation sequencing analysis in hematological malignanciesMohamed Chafiq — 2013
• Molecular evaluation of DNMT3A and IDH1/2 gene mutation: frequency, distribution pattern and associations with additional molecular markers in normal karyotype Indian acute myeloid leukemia patients.D. R. Ramesh Singh — 2014
• New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma直也 片山, 秀成 髙 — 2015
• Next Generation Sequencing of Acute Myeloid Leukemia: Influencing PrognosisHans J. Blommestein — 2015
• Hematopoietic stem cell transplantation for adult patients with isolated NPM1 mutated acute myeloid leukemia in first remissionXavier Baró i Queralt — 2018
• Emerging drug profile: Krebs cycle and cancer: IDH mutations and therapeutic implicationsJ.A. Kornfeld — 2019
• Manipulation du métabolisme énergétique dans les leucémies aiguës myéloïdes : mitochondrie, apoptose et mécanisme d'action de la metformineSarah J. Scotland — 2013
• Acute Myeloid Leukemia, Genetics, and Risk Stratification: Data Overload or Ready for a Breakthrough?Simon B. Zeichner — 2012
• Topics in cancer genomicsSachet A. Shukla — 2014
• Studies on CEBPA mutations in acute myeloid leukaemiaGreen Cl — 2012
• Mutations de gènes impliqués dans le métabolisme énergétique et cancerConstance Thibault, Anne‐Paule Gimenez‐Roqueplo — 2013
• Aktuelle Behandlungsmöglichkeiten akuter myeloischer LeukämienMichael Heuser, Richard F. Schlenk, Arnold Ganser — 2011
• Prognostic markers in pediatric leukemia and mechanisms of KRAS induced leukemogenesisAnna Staffas — 2013
• Rôle des anomalies de TET2 dans la transformation tumorale lymphoïde et myéloïdeLucile Couronné — 2012
• Cytosine modifications in myeloid malignancies.Kristen Meldi, María E. Figueroa — 2015
• Molecular Characterization of Genetic and Epigenetic Alterations in GliomasChristopher G. Duncan — 2012

Related papers

• Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma?Nanne K. Kloosterhof, Linda B.C. Bralten, Hendrikus J. Dubbink — 2011
• Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic ReviewAlexander Yuile, Laveniya Satgunaseelan, Joe Wei — 2022
• Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic targetChangcun Guo, Christopher J. Pirozzi, Giselle Y. López — 2011
• IDH1 and IDH2 Mutations in GliomasHai Yan, D. Williams Parsons, Genglin Jin — 2009
• Molecular investigation of isocitrate dehydrogenase gene (IDH) mutations in gliomas: first report of IDH2 mutations in Indian patients.Bibhu Ranjan Das, Rajiv Tangri, Firoz Ahmad — 2013
• Mutant Metabolic Enzymes Are at the Origin of GliomasHai Yan, Darell D. Bigner, Victor E. Velculescu — 2009
• Epidemiological Study of Molecular and Genetic Classification in Adult Diffuse GliomaMohammad Faraji-Rad — 2022
• Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors.Xiang Liu, Zhi‐Qiang Ling — 2015
• 2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase MutationsGenglin Jin, Zachary J. Reitman, Ivan Spasojević — 2011
• Effects of IDH1 and IDH2 genes mutations on tumorsXiang Liu — 2015