Testosterone and Dihydrotestosterone Tissue Levels in Recurrent Prostate Cancer
Explore this paper's citation graph
Summary
Recurrent prostate cancer may develop the capacity to biosynthesize testicular androgens from adrenal androgens or cholesterol, a surprising finding that suggests intracrine production of dihydrotestosterone should be exploited for novel treatment of recurrent prostate cancer.
- Type
- article
- Published
- 2005-07-01
- Cited by
- 514
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W2150609534
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2346164
Keywords
Prostate cancer, Dihydrotestosterone, Testosterone (patch), Androgen, Prostate
References
- Altered androgen metabolism in metastatic prostate cancer.
- Distant metastases from prostatic carcinoma express androgen receptor protein.
- Androgen receptor: A key molecule in the progression of prostate cancer to hormone independence
- The embedded tumour: host physiology is important for the evaluation of tumour growth
- Cholesterol and prostate cancer
- Steroid levels in cancer of the prostate--markers of tumour differentiation and adequacy of anti-androgen therapy.
- Molecular determinants of resistance to antiandrogen therapy
- The development of androgen-independent prostate cancer
- Androgen receptors in endocrine‐therapy‐resistant human prostate cancer
- Amplification of the androgen receptor gene in bone metastases from hormone‐refractory prostate cancer
- 5alpha-reductase type 1 immunostaining is enhanced in some prostate cancers compared with benign prostatic hyperplasia epithelium.
- Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men.
- The Influence of Androgen Deprivation Therapy on Dihydrotestosterone Levels in the Prostatic Tissue of Patients with Prostate Cancer
- Antagonist/Agonist Balance of the Nonsteroidal Antiandrogen Bicalutamide (Casodex) in a New Prostate Cancer Model
- Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.
- DHT concentrations in human prostate cancer tissue.
- Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system
- Androgen receptor signaling in androgen-refractory prostate cancer.
- Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.
- A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy.
Cited by
- Die Rolle des Androgenrezeptors im hormonrefraktären Prostatakarzinom
- Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.
- Insulin increases de novo steroidogenesis in prostate cancer cells.
- Endothelial cells enhance prostate cancer metastasis via IL6→androgen receptor→TGFβ→MMP9 signals
- Mechanisms of resistance in castration-resistant prostate cancer (CRPC)
- Current and potential targets for drug design in the androgen receptor pathway for prostate cancer
- Mechanisms of prostate cancer initiation and progression.
- Der alternative Androgensyntheseweg des Menschen
- CYP17A1 polymorphisms and clinical outcome of patients with metastatic castration-resistant prostate cancer treated with abiraterone
- Functional significance of androgen receptor mutations in prostate and breast cancer
- The role of insulin in advanced prostate cancer
- “Getting from here to there” - Mechanisms and Limitations to the Activation of the Androgen Receptor in Castration-Resistant Prostate Cancer
- The role of insulin and IGF2 signalling on metabolic pathways in prostate cancer progression
- Androgen receptor coactivators and prostate cancer.
- APPLICATION OF TARGETING NUCLEASES TO MODELING PROSTATE CANCER GENE REARRANGEMENTS.
- Sequencing of agents for castration-resistant prostate cancer.
- Therapy of Prostate Cancer Using a Human Antibody Targeting the Type 1 Insulin-Like Growth Factor Receptor (IGF-IR)
- Castration-recurrent prostate cancer is not androgen-independent.
- 외부성기의 이상을 보이는 유전적 남아에서 생식기 섬유아세포 안드로겐 수용체의 Dihydrotestosterone과의 결합능과 수용체 유전자 돌연변이에 관한 연구
- Current treatments and novel therapeutic targets for castration resistant prostate cancer with bone metastasis.
Related papers
- The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men.
- Testosterone, androstenedione and dihydrotestosterone: Effects on mating behavior of male rats
- Metabolic clearance rate and blood production rate of testosterone and dihydrotestosterone in normal subjects, during pregnancy, and in hyperthyroidism.
- The source of plasma dihydrotestosterone in man.
- Studies on the dynamics of plasma androgens and on the origin of dihydrotestosterone in dogs.
- Localization of androgenic metabolites in the brain of rats administered testosterone or dihydrotestosterone.
- [Blood levels of testosterone and dihydrotestosterone in breast cancer].
- Plasma levels of dihydrotestosterone remain in the normal range in men treated with long‐acting parenteral testosterone undecanoate
- Response-surface modeling of the effect of 5alpha-dihydrotestosterone and androgen receptor levels on the response to the androgen antagonist vinclozolin.
- The mechanism of androgen uptake and concentration by rat ventral prostate in organ culture.