PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
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Summary
Hypoxia selectively up-regulates PD-L1 on myeloid-derived suppressor cells via HIF-1a, thus affecting T cell activation.
- Type
- article
- Published
- 2014-05-05
- Cited by
- 1,948
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W2149360266
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1808681
Keywords
Cancer research, Tumor microenvironment, CD86, Myeloid-derived Suppressor Cell, Hypoxia (environmental)
References
- The Cooperative Induction of Hypoxia-Inducible Factor-1α and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis12
- Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice
- Hypoxia-inducible factor-1 alpha–dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
- IL-10 Immunomodulation of Myeloid Cells Regulates a Murine Model of Ovarian Cancer
- Oxygen sensing, homeostasis, and disease.
- Interferon regulatory factor‐1 is prerequisite to the constitutive expression and IFN‐γ‐induced upregulation of B7‐H1 (CD274)
- Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation.
- PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells.
- Abstract 4629: Tumor penetration and retention of different sized FGFR4 targeting scaffolds
- Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity
- Coordinated regulation of myeloid cells by tumours
- The blockade of immune checkpoints in cancer immunotherapy
- Microenvironment of the murine mammary carcinoma 4T1: endogenous IFN-gamma affects tumor phenotype, growth, and metastasis.
- Regulatory T cells stimulate B7-H1 expression in myeloid-derived suppressor cells in ret melanomas.
- Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia.
- Tumor Cell Programmed Death Ligand 1-Mediated T Cell Suppression Is Overcome by Coexpression of CD80
- Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
- HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
- Immortalized Myeloid Suppressor Cells Trigger Apoptosis in Antigen-Activated T Lymphocytes1
- PD-1 and PD-1 ligands: from discovery to clinical application.
Cited by
- CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients.
- A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
- PD-1 and its ligands are important immune checkpoints in cancer
- Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters
- PD-1 and PD-L1 expression in 132 recurrent nasopharyngeal carcinoma: the correlation with anemia and outcomes.
- The optimism surrounding stereotactic body radiation therapy and immunomodulation.
- Cancer Immunotherapy: A Focus on the Regulation of Immune Checkpoints
- Myeloid‐derived suppressor cells and tumor: Current knowledge and future perspectives
- The emerging roles of macrophages in cancer metastasis and response to chemotherapy
- Podoplanin Positive Myeloid Cells Promote Glioma Development by Immune Suppression
- Tumor-associated myeloid cells: diversity and therapeutic targeting
- Myeloid-Derived Suppressor Cells: Critical Cells Driving Immune Suppression in the Tumor Microenvironment
- Beyond Adjuvants: Immunomodulation strategies to enhance T cell immunity
- IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection
- Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma
- Snap-shot multispectral imaging of vascular dynamics in a mouse window chamber model
- Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
- CXCR4 inhibition in tumor microenvironment facilitates anti-PD-1 immunotherapy in sorafenib-treated HCC in mice
- Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment
- Regulation of immunopathology in hepatitis B virus infection
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