Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A

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Summary

These experiments demonstrate that, in addition to its ability to package cyclophilin A into virions, gag encodes the functional target of cyclosporine A, indicating that the drug-resistant mutants do not require virion-associated cyclophin A to initiate infection.

Type
article
Published
1996-08-01
Cited by
160
References
41
Access
Open access

Keywords

Cyclophilin A, Cyclophilin, Peptidylprolyl isomerase, Biology, Cis-trans-Isomerases

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