Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A
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Summary
These experiments demonstrate that, in addition to its ability to package cyclophilin A into virions, gag encodes the functional target of cyclosporine A, indicating that the drug-resistant mutants do not require virion-associated cyclophin A to initiate infection.
- Type
- article
- Published
- 1996-08-01
- Cited by
- 160
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W2146734555
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25409219
Keywords
Cyclophilin A, Cyclophilin, Peptidylprolyl isomerase, Biology, Cis-trans-Isomerases
References
- Retroviral RNA packaging: sequence requirements and implications.
- The effect of cyclosporine A on infection of susceptible cells by human immunodeficiency virus type 1.
- The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin.
- Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene
- Enzymatic dissociation of clathrin cages in a two-stage process.
- Catalysis of protein folding by cyclophilins from different species.
- Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein
- Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex
- Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein
- The nonmyristylated Pr160gag-pol polyprotein of human immunodeficiency virus type 1 interacts with Pr55gag and is incorporated into viruslike particles
- Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
- The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions
- Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription
- Requirements for incorporation of Pr160gag-pol from human immunodeficiency virus type 1 into virus-like particles
- Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins
- Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506.
- Proline isomerases function during heat shock.
- Isomerase and chaperone activity of prolyl isomerase in the folding of carbonic anhydrase.
- Cyclophilin catalyzes protein folding in yeast mitochondria.
- Specific incorporation of cyclophilin A into HIV-1 virions
Cited by
- NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells.
- Towards the Development of Synergistic Inhibitors that Exploit the Replication Strategy of HIV-1
- Lentiviral gene therapy for HIV using TRIM-cyclophilin restriction factors
- Rôle de la lysyl-ARNt synthétase mitochondriale humaine dans la réplication du VIH-1
- Learning from the past: Searching for novel TRIM, CypA, and TRIMCyp antiviral factors in primates
- IMMUNE ACTIVATION AND CIGARETTE SMOKE EXPOSURE AS POTENTIAL DETERMINANTS OF FAILURE OF HAART IN THE SETTING OF MOTHER-TO- CHILD TRANSMISSION.
- Cells with High Cyclophilin A Content Support Replication of Human Immunodeficiency Virus Type 1 Gag Mutants with Decreased Ability To Incorporate Cyclophilin A
- Novel Activities of Cyclophilin A and Cyclosporin A during HIV-1 Infection of Primary Lymphocytes and Macrophages1
- New targets for inhibitors of HIV-1 replication
- HIV-1 Capsid: The Multifaceted Key Player in HIV-1 infection
- Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions
- Role of the Capsid Helix 4-5 Loop in Equine Infectious Anemia Virus Infection
- The functional interplay between TNPO3, CPSF6 and HIV-1 CA
- HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry
- Cyclophilin A-Dependent Restriction of Human Immunodeficiency Virus Type 1 Capsid Mutants for Infection of Nondividing Cells
- Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes.
- Host factors involved in resistance to retroviral infection
- HIV-host interactions: vital to the virus and key to its inhibition.
- Cyclophilin A regulates HIV‐1 infectivity, as demonstrated by gene targeting in human T cells
- Binding and Susceptibility to Postentry Restriction Factors in Monkey Cells Are Specified by Distinct Regions of the Human Immunodeficiency Virus Type 1 Capsid
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