The role of oxidative stress in the pathogenesis of age-related macular degeneration.
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Summary
The concept that AMD can be attributed to cumulative oxidative stress is enticing, but remains unproven, and the effect of nutritional antioxidant supplements on the onset and natural course of age-related macular disease is currently being evaluated.
- Type
- review
- Published
- 2000-09-01
- Cited by
- 2,048
- References
- 231
- OpenAlex
- https://openalex.org/W2144839999
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46626678
Keywords
Oxidative stress, Zeaxanthin, Macular degeneration, Lipofuscin, Lutein
References
- The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium.
- Toxicological significance of metallothionein.
- Trace Element Status and Free Radical Defense in Elderly Rhesus Macaques (Macaca mulatta) with Macular Drusen
- Antioxidant Action of Carotenoids in Vitro and in Vivo and Protection against Oxidation of Human Low‐Density Lipoproteins a , b
- Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study.
- Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina.
- Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells.
- Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells.
- Failure of vitamin E to protect the retina against damage resulting from bright cyclic light exposure.
- The rod outer segment phospholipid/opsin ratio of rats maintained in darkness or cyclic light.
- The metabolism of omega-3 polyunsaturated fatty acids in the eye: the possible role of docosahexaenoic acid and docosanoids in retinal physiology and ocular pathology.
- Fatty acid composition of the human macula and peripheral retina.
- Distribution of individual macular pigment carotenoids in central retina of macaque and squirrel monkeys.
- Measurement of carotenoids, retinoids, and tocopherols in human lenses.
- Metallothionein shows an age-related decrease in human macular retinal pigment epithelium.
- Content and state of glntathione in the tissues of the eye.
- The fate of the phagosome: conversion to 'age pigment' and impact in human retinal pigment epithelium.
- Superoxide dismutase in ocular structures.
- Sensitivities in older eyes with good acuity: eyes whose fellow eye has exudative AMD.
- Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes.
Cited by
- Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: implications for age-related macular degeneration.
- Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization.
- Surgery for macular disease
- Central retinal thickness is positively correlated with macular pigment optical density.
- Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi;Fructus barbarum L.)
- Expression pattern of metallothionein, MTF‐1 nuclear translocation, and its dna‐binding activity in zebrafish (Danio rerio) induced by zinc and cadmium
- The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE.
- Diarylheptanoid 7-(3,4 dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene from Curcuma comosa Roxb. protects retinal pigment epithelial cells against oxidative stress-induced cell death.
- Do Nutritional Supplements Have a Role in Age Macular Degeneration Prevention?
- Why has Nature Chosen Lutein and Zeaxanthin to Protect the Retina?
- Nutrition and age-related macular degeneration: research evidence in practice.
- Induced Pluripotent Stem Cells Without c-Myc Ameliorate Retinal Oxidative Damage via Paracrine Effects and Reduced Oxidative Stress in Rats
- Gene Ontology and KEGG Enrichment Analyses of Genes Related to Age-Related Macular Degeneration
- The effect of visual blue light on mitochondrial function associated with retinal ganglions cells.
- Expression of Endoplasmic Reticulum Stress Markers GRP78 and CHOP Induced by Oxidative Stress in Blue Light-Mediated Damage of A2E-Containing Retinal Pigment Epithelium Cells
- Effect of taurine on antioxidant enzyme system in B16F10 melanoma cells.
- NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice
- Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration.
- Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
- Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells
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