Mixed linear model approach adapted for genome-wide association studies
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Summary
A compression approach is reported, called 'compressed MLM', that decreases the effective sample size of such datasets by clustering individuals into groups and a complementary approach, 'population parameters previously determined' (P3D), that eliminates the need to re-compute variance components.
- Type
- article
- Published
- 2010-03-07
- Cited by
- 2,035
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W2141916112
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9702367
Keywords
Genetic association, Genome-wide association study, Biology, Linear model, Population
References
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- Data clustering: a review
- Cluster analysis for researchers
- Definition of Group Effects in Sire Evaluation Models
- Genomic Control for Association Studies
- Spatial genetic structure of a tropical understory shrub, PSYCHOTRIA OFFICINALIS (RuBIACEAE)
- Power of in silico QTL mapping from phenotypic, pedigree, and marker data in a hybrid breeding program
- The long (and winding) road to gene discovery for canine hip dysplasia
- Estimation of heritabilities, genetic correlations, and breeding values of four traits that collectively define hip dysplasia in dogs.
- The empirical Bayes approach: estimating the prior distribution.
- A general test of association for quantitative traits in nuclear families.
- Inference of population structure using multilocus genotype data.
- Association Mapping: Critical Considerations Shift from Genotyping to Experimental Design
Cited by
- High-throughput Genome-wide Association Analysis for Single and Multiple Phenotypes
- Lassoing and Corralling Rooted Phylogenetic Trees
- The identification of 14 new genes for meat quality traits in chicken using a genome-wide association study
- Statistical perspectives for genome-wide association studies (GWAS).
- Genome-wide association study (GWAS) of carbon isotope ratio (δ13C) in diverse soybean [Glycine max (L.) Merr.] genotypes
- Analysis of baseline, average, and longitudinally measured blood pressure data using linear mixed models
- Genome-Wide Association Study of Anthracnose Resistance in Andean Beans (Phaseolus vulgaris)
- Genome‐Wide Association Mapping of Fusarium Head Blight Resistance in Wheat using Genotyping‐by‐Sequencing
- Genome‐Wide Association Analysis Reveals Different Genetic Control in Panicle Architecture Between Indica and Japonica Rice
- Clubroot resistance QTL are modulated by nitrogen input in Brassica napus
- Computer vision and machine learning for robust phenotyping in genome-wide studies
- Loci associated with resistance to stripe rust (Puccinia striiformis f. sp. tritici) in a core collection of spring wheat (Triticum aestivum)
- Loci and candidate genes conferring resistance to soybean cyst nematode HG type 2.5.7
- Main and epistatic loci studies in soybean for Sclerotinia sclerotiorum resistance reveal multiple modes of resistance in multi-environments
- An efficient unified model for genome-wide association studies and genomic selection
- Genetic Variation and Association Mapping of Seed-Related Traits in Cultivated Peanut (Arachis hypogaea L.) Using Single-Locus Simple Sequence Repeat Markers
- An integrated multi‐layered analysis of the metabolic networks of different tissues uncovers key genetic components of primary metabolism in maize
- Association of yield-related traits in founder genotypes and derivatives of common wheat (Triticum aestivum L.)
- Hair, encoding a single C2H2 zinc‐finger protein, regulates multicellular trichome formation in tomato
- Genetic dissection of protein and starch during wheat grain development using QTL mapping and GWAS
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