Vascular endothelial growth factor (VEGF) and its receptors
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Summary
Recent developments that have widened considerably the understanding of the mechanisms that control V EGF production and VEGF signal transduction are focused on and recent studies that have shed light on the mechanisms by which VEGf regulates angiogenesis are reviewed.
- Type
- article
- Published
- 1999-01-01
- Cited by
- 3,658
- References
- 185
- OpenAlex
- https://openalex.org/W2141046053
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1151216
Keywords
VEGF receptors, Vascular endothelial growth factor C, Vascular endothelial growth factor, Vascular endothelial growth factor B, Receptor
References
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- Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression
- The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
- A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.
- Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene.
- The second immunoglobulin‐like domain of the VEGF tyrosine kinase receptor Flt‐1 determines ligand binding and may initiate a signal transduction cascade.
- Angiogenesis and angiogenesis inhibition: an overview.
- Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine.
- Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.
- Roles of vascular endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity.
- Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.
- Characterization of the receptor to vasculotropin on bovine adrenal cortex-derived capillary endothelial cells.
- Neovasculature induced by vascular endothelial growth factor is fenestrated.
- Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
- The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.
- p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.
- The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.
- Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization.
- V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.
Cited by
- Immune dysfunction in cancer patients.
- Vascular endothelial growth factor (VEGF) is expressed during articular cartilage growth and re-expressed in osteoarthritis.
- Supresión de la angiogénesis tumoral a través de anticuerpos monoclonales
- Expression of Vascular Endothelial Growth Factor-A and its Receptors in Uteroplacental Tissues of the Normotensive and Hypertensive Pregnant Rat
- Short title for running head: VEGFR-3+ lymphatic/vascular endothelial precursors
- Applications of magnetic resonance in model systems: tumor biology and physiology.
- Vascular endothelial growth factor and its correlation with angiogenesis and p53 expression in prostate cancer
- TerplexDNA gene carrier system targeting artery wall cells.
- Bioimmunotherapeutic targets on angiogenetic blood vessels in solid malignangies.
- Endothelial nitric oxide synthase is strongly expressed in malignant mesothelioma but does not associate with vascular density or the expression of VEGF, FLK1 or FLT1
- From the discovery of neuropilin to the determination of its adhesion sites.
- Vitreous fluid biomarkers.
- Experimental angiogenesis of arterial vasa vasorum
- Quantitative RT-PCR Assay for VEGF Mrna in Human Tumors of the Kidney
- New Molecular Targets of Breast Cancer Therapy
- Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent.
- VEGF-RII Influences the Prognosis of Pancreatic Cancer
- Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation
- Angiogenesis of the heart
- Growth factors in the treatment of diabetic foot ulcers
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