Nod1 Participates in the Innate Immune Response to Pseudomonas aeruginosa*

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Summary

It is demonstrated that Nod1 detects the P. aeruginosa peptidoglycan leading to NF-κB activation and that this activity is diminished in epithelial cells expressing a dominant-negative Nod 1 construct or in mouse embryonic fibroblasts from Nod2 knock-out mice infected with P.aeruginose.

Type
article
Published
2005-11-04
Cited by
178
References
36
Access
Open access

Keywords

NOD1, Peptidoglycan, Innate immune system, Microbiology, Pseudomonas aeruginosa

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