Nod1 Participates in the Innate Immune Response to Pseudomonas aeruginosa*
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Summary
It is demonstrated that Nod1 detects the P. aeruginosa peptidoglycan leading to NF-κB activation and that this activity is diminished in epithelial cells expressing a dominant-negative Nod 1 construct or in mouse embryonic fibroblasts from Nod2 knock-out mice infected with P.aeruginose.
- Type
- article
- Published
- 2005-11-04
- Cited by
- 178
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2138494261
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41575151
Keywords
NOD1, Peptidoglycan, Innate immune system, Microbiology, Pseudomonas aeruginosa
References
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- Mini‐review: The role of peptidoglycan recognition in innate immunity
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- Pseudomonas aeruginosa internalization by human epithelial respiratory cells depends on cell differentiation, polarity, and junctional complex integrity.
- Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
- RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
- Synergistic stimulation of human monocytes and dendritic cells by Toll‐like receptor 4 and NOD1‐ and NOD2‐activating agonists
- CXC Chemokine Receptor CXCR2 Is Essential for Protective Innate Host Response in Murine Pseudomonas aeruginosaPneumonia
- Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection*
Cited by
- Role of Nods in bacterial infection.
- Characterization of Rabbit Nucleotide-Binding Oligomerization Domain 1 (NOD1) and the Role of NOD1 Signaling Pathway during Bacterial Infection
- Identification de facteurs génétiques contrôlant la résistance de lignées de souris consanguines à une infection expérimentale par Yersinia pestis, l'agent de la peste
- La réponse immunitaire à l’agression: le B.A.-BA — Système immunitaire inné
- Impaired Pulmonary Host Defense Against Pseudomonas aeruginosa Following Bone Marrow Transplantation.
- Modulation de la réponse immunitaire par TLR7: rôle dans le diabète de type 1 et l'asthme allergique.
- Recognition and cytokine signalling pathways in host defence against Aspergillus fumigatus
- Innate immune defence to Helicobacter pylori.
- Chimiokines et interaction entre l'immunité innée et adaptative dans l'asthme allergique : implication des cellules dendritiques et du récepteur NOD1
- Therapeutic targeting of NOD1 receptors
- Pseudomonas aeruginosa: Host defence in lung diseases
- Innate receptors and cellular defense against pulmonary infections
- The Role of Rip2 Protein in the Nod Mediated Innate Immune Response: A Dissertation
- Klebsiella pneumoniae subverts the activation of inflammatory responses in a NOD1‐dependent manner
- The role of cytokines and pattern-recognition receptors in inflammatory gastrointestinal diseases: clinical and in vitro investigations
- Sensing intracellular pathogens-NOD-like receptors.
- Dampening Host Sensing and Avoiding Recognition in Pseudomonas aeruginosa Pneumonia
- The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.
- Function of Nod-like Receptors in Microbial Recognition and Host Defense
- NOD-like receptors and the innate immune system: coping with danger, damage and death.
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