Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.
Explore this paper's citation graph
Summary
The results support the importance of heart-rate reduction with ivabradine for improvement of clinical outcomes in heart failure and confirm the important role of heart rate in the pathophysiology of this disorder.
- Type
- article
- Published
- 2010-09-11
- Cited by
- 2,161
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W2136642260
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21196422
Keywords
Ivabradine, Medicine, Heart failure, Placebo, Clinical endpoint
References
- Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)
- [Beta-blockers in chronic heart failure].
- &bgr;-Blockers in Chronic Heart Failure
- Long-Term Trends in First Hospitalization for Heart Failure and Subsequent Survival Between 1986 and 2003: A Population Study of 5.1 Million People
- Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure.
- Adequacy of diagnosis and treatment of chronic heart failure in primary health care in Sweden
- Ventricular remodeling in heart failure and the effect of beta-blockade.
- Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group.
- The EuroHeart Failure Survey programme--a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment.
- Is the gap between guidelines and clinical practice in heart failure treatment being filled? Insights from the IMPACT RECO survey
- Heart Rate and Cardiac Rhythm Relationships With Bisoprolol Benefit in Chronic Heart Failure in CIBIS II Trial
- Rationale and design of a randomized, double‐blind, placebo‐controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial (SHIFT)
- The myocardium in congestive heart failure.
- Effects of metoprolol and carvedilol on cause-specific mortality and morbidity in patients with chronic heart failure--COMET.
- Analysis of randomized controlled trials on the effect of magnitude of heart rate reduction on clinical outcomes in patients with systolic chronic heart failure receiving beta-blockers.
- Survival trends in men and women with heart failure of ischaemic and non-ischaemic origin: data for the period 1987-2003 from the Swedish Hospital Discharge Registry.
- Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease.
- Funny channels in the control of cardiac rhythm and mode of action of selective blockers.
- Predictors of mortality and morbidity in patients with chronic heart failure.
- Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial.
Cited by
- Ivabradine: a ray of hope for inappropriate sinus tachycardia.
- Neue Substanzen in der Therapie der Angina pectoris
- Ivabradine added to guidelines-based therapy in systolic heart failure patients
- Effect of Carvedilol, Ivabradine or their combination on exercise capacity in patients with Heart Failure (the CARVIVA HF trial).
- Cardioprotection by Ivabradine Through Heart Rate Reduction and Beyond
- Almanac 2011: heart failure. The national society journals present selected research that has driven recent advances in clinical cardiology.
- Konservative Therapie der stabilen koronaren Herzkrankheit
- Baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF)
- Inconsistencies in the development of the ESC Clinical Practice Guidelines for Heart Failure.
- Case selection for cardiac resynchronization in atrial fibrillation.
- I(f) current inhibitor ivabradine in patients with idiopathic dilated cardiomyopathy: Impact on the exercise tolerance and quality of life.
- Heart rate reduction and longevity in mice
- Ivabradine reduces myocardial stunning in patients with exercise-inducible ischaemia
- Ruhepuls und funktionelle Einschränkungen als prognostische Parameter bei herzinsuffizienten Patienten im tatsächlichen Leben. Daten aus dem Herzinsuffizienz-Register der ÖKG
- Effect of resting heart rate on two-year clinical outcomes of high-risk patients with severe symptomatic aortic stenosis undergoing transcatheter aortic valve implantation.
- Control of sinus tachycardia as an additional therapy in patients with decompensated heart failure (CONSTATHE-DHF): A randomized, double-blind, placebo-controlled trial.
- Ivabradine in the treatment of systolic heart failure - A systematic review and meta-analysis
- Current Pharmacological Therapies in Heart Failure Patients
- The prognostic significance of heart rate in patients hospitalized for heart failure with reduced ejection fraction in sinus rhythm: insights from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study With Tolvaptan) trial.
- Does a Target Dose or a Target Heart Rate Matter to Outcomes When Prescribing β-Blockers to Patients With Chronic Heart Failure?
Related papers
- Advances in Using Ivabradine in Cardiovascular Disease
- Clinical Efficacy of Ivabradine
- Characterization of the Heart Rate-Lowering Action of Ivabradine, a Selective If Current Inhibitor
- Ivabradine, A Heart Rate Lowering Drug: A Clinical Investigation
- Why do I use ivabradine in my patients?
- Clinical Results of If Current Inhibition by Ivabradine
- The Efficacy of Ivabradine Alone, Metoprolol Alone and Combination of Ivabradine and Metoprolol in Reducing Heart Rate Among Patients Undergoing Computed Tomography Coronary Angiography
- Effect of Graded Heart Rate Reduction with Ivabradine on Myocardial Oxygen Consumption and Diastolic Time in Exercising Dogs
- Impact of ivabradine on dyspnea in patient with moderate mitral stenosis in sinus rhythm
- ROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILURE