Antioxidant metallothionein alleviates endoplasmic reticulum stress-induced myocardial apoptosis and contractile dysfunction
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Summary
The data favor a beneficial effect of metallothionein against ER stress-induced cardiac dysfunction possibly associated with attenuation of myocardial apoptosis.
- Type
- article
- Published
- 2015-05-12
- Cited by
- 21
- References
- 62
- OpenAlex
- https://openalex.org/W2128747093
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:207518271
Keywords
Tunicamycin, Endoplasmic reticulum, Unfolded protein response, Apoptosis, Oxidative stress
References
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- Salubrinal protects against tunicamycin and hypoxia induced cardiomyocyte apoptosis via the PERK-eIF2α signaling pathway
- Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor.
- ER stress and diseases
- Cytotoxicity of Nitric Oxide Is Alleviated by Zinc-Mediated Expression of Antioxidant Genes
- Reactivity of Zn-, Cd-, and Apo-Metallothionein with Nitric Oxide Compounds: In Vitro and Cellular Comparison
- Cardioprotection by Endoplasmic Reticulum Stress–Induced Autophagy
- Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy
- Insulin-Like Growth Factor I
- Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) upregulation contribute to the onset of diabetic cardiomyopathy
- Cardiac Overexpression of Metallothionein Rescues Cardiac Contractile Dysfunction and Endoplasmic Reticulum Stress But Not Autophagy in Sepsis
- Endoplasmic reticulum Chaperon Tauroursodeoxycholic Acid Alleviates Obesity-Induced Myocardial Contractile Dysfunction
- Retracted: Activation of Akt Rescues Endoplasmic Reticulum Stress-Impaired Murine Cardiac Contractile Function via Glycogen Synthase Kinase-3β-Mediated Suppression of Mitochondrial Permeation Pore Opening
- New directions in ER stress-induced cell death
- Cardiac-Specific Overexpression of Metallothionein Rescues against Cigarette Smoking Exposure-Induced Myocardial Contractile and Mitochondrial Damage
- Metallothionein Inhibits Peroxynitrite-induced DNA and Lipoprotein Damage*
- Heavy metal scavenger metallothionein mitigates deep hypothermia-induced myocardial contractile anomalies: role of autophagy.
- Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.
- Aquaporin-assisted and ER-mediated mitochondrial fission: A hypothesis
- Thapsigargin Triggers Cardiac Contractile Dysfunction via NADPH Oxidase -Mediated Mitochondrial Dysfunction: Role of Akt Dephosphorylation
Cited by
- Metallothionein differentially affects the host response to Listeria infection both with and without an additional stress from cold-restraint
- Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice
- Toll‐like receptor 4 ablation rescues against paraquat‐triggered myocardial dysfunction: Role of ER stress and apoptosis
- Mammalian Metallothionein-2A and Oxidative Stress
- Metallothioneins regulate the adipogenic differentiation of 3T3-L1 cells via the insulin signaling pathway
- Reappraisal of metallothionein: Clinical implications for patients with diabetes mellitus
- The effects of putrescine are partly overlapping with osmotic stress processes in wheat.
- Aberrant endoplasmic reticulum stress mediates coronary artery spasm through regulating MLCK/MLC2 pathway
- Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes
- Role of endoplasmic reticulum stress and protein misfolding in disorders of the liver and pancreas.
- Cardiac‐specific overexpression of metallothionein attenuates L‐NAME‐induced myocardial contractile anomalies and apoptosis
- Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedema
- Single-cell RNA sequencing of subcutaneous adipose tissues identifies therapeutic targets for cancer-associated lymphedema
- Sphingosine-1-phosphate Attenuates Endoplasmic Reticulum Stress-induced Cardiomyocyte Apoptosis Through Sphingosine-1-phosphate Receptor 1.
- Sacrificing Adaptability for Functionality: The Ivory Tower of Macular Müller Cells
- Downregulating miR-432-5p exacerbates adriamycin-induced cardiotoxicity via activating the RTN3 signaling pathway
- An antireductant approach ameliorates misfolded proinsulin-induced hyperglycemia and glucose intolerance in male Akita mice
- Activation of Protein Kinase B Rescues against Thapsigargin-Elicited Cardiac Dysfunction through Regulation of NADPH Oxidase and Ferroptosis.
- Divergent redox responses of macular and peripheral Müller Glia: Implications for retinal vulnerability
- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction
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