Genetic organization and diversity of the hepatitis C virus.
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Summary
The nucleotide sequence of the RNA genome of the human hepatitis C virus has been determined and significant genome diversity is apparent within the putative 5' structural gene region of different HCV isolates, suggesting the presence of closely related but distinct viral genotypes.
- Type
- article
- Published
- 1991-03-15
- Cited by
- 1,777
- References
- 4
- Access
- Open access
- OpenAlex
- https://openalex.org/W2124528668
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20603652
Keywords
Biology, Genetics, Nucleic acid sequence, Virology, Peptide sequence
References
Cited by
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- Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation
- Detection of replicative intermediates of viral RNA in peripheral blood mononuclear cells from chronic hepatitis C virus carriers.
- Detection of a 5' UTR variation in the HCV genome after a long-term in vitro infection.
- HCV genotypes in Swedish blood donors as correlated to epidemiology, liver disease and hepatitis C virus antibody profile
- Restriction of hepatitis C virus heterogeneity during prolonged interferon-alpha therapy in relation to changes in virus load.
- Serological pattern of hepatitis C virus recurrence after liver transplantation.
- Virology of hepatitis C virus
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- Serological Differentiation between HCV Subtypes 1a and 1b by a Recombinant Immunoblot Assay
- Ribozyme gene therapy for hepatitis C virus infection.
- Typing of Hepatitis C Virus by a New Method Based on Restriction Fragment Length Polymorphism
- Clinical Significance of Hepatitis C Virus Genotypes
- Inducible model to study negative strand RNA synthesis and assembly of hepatitis C virus from a full-length cDNA clone.
- Analysis of the C-Terminal Membrane Anchor Domains of Hepatitis C Virus Glycoproteins E1 and E2: toward a Topological Model
- Hepatitis C Virus Genotyping: Interrogation of the 5′ Untranslated Region Cannot Accurately Distinguish Genotypes 1a and 1b
- Sensitivity and reproducibility of HCV quantitation in chimpanzee sera using TaqMan real-time PCR assay.
- Comparative rates of nucleotide sequence variation in the hypervariable region of E1/E2 and the NS5b region of hepatitis C virus in patients with a spectrum of liver disease resulting from a common source of infection.
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