Genetic dissection of complex traits.
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Summary
This article synthesizes the current state of the genetic dissection of complex traits--describing the methods, limitations, and recent applications to biological problems.
- Type
- review
- Published
- 1994-09-30
- Cited by
- 1,863
- References
- 260
- OpenAlex
- https://openalex.org/W2123466824
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11102381
Keywords
Mendelian inheritance, Biology, Inheritance (genetic algorithm), Allele, Genetics
References
- Fitting genetic data using Gibbs sampling: an application to nevus counts in 38 Utah kindreds.
- Genetic heterogeneity in the cerebrohepatorenal (Zellweger) syndrome and other inherited disorders with a generalized impairment of peroxisomal functions. A study using complementation analysis.
- The investigation of linkage between a quantitative trait and a marker locus
- Clinical diversity of sickle cell anemia: Genetic and cellular modulation of disease severity
- Combined analysis of genetic segregation and linkage under an oligogenic model.
- Selecting pedigrees for linkage analysis of a quantitative trait: the expected number of informative meioses.
- Maximum likelihood estimation by counting methods under polygenic and mixed models in human pedigrees.
- Linkage strategies for genetically complex traits. I. Multilocus models.
- Cutting a Gordian knot in the linkage analysis of complex human traits.
- Testing separate families of segregation hypotheses: bootstrap methods.
- Ataxia-telangiectasia: linkage evidence for genetic heterogeneity.
- The affected sib-pair method using identity by state relations.
- Multipoint analysis of human quantitative genetic variation.
- A multilocus extension of the affected-pedigree-member method of linkage analysis.
- Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations.
- Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent.
- Linkage analysis of quantitative traits: increased power by using selected samples.
- Efficient strategies for genomic searching using the affected-pedigree-member method of linkage analysis.
- Correcting for single ascertainment by truncation for a quantitative trait.
- Linkage analysis of maturity-onset diabetes of the young (MODY): genetic heterogeneity and nonpenetrance.
Cited by
- Statistical Aspect of Trait Mapping Using a Dense Set of Markers: A Partial Review
- Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy.
- Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol
- Polymorphism in the cytochrome P450 2E1 gene and alcohol-induced disorders of human spermatogenesis.
- Genetically complex cardiovascular traits. Origins, problems, and potential solutions.
- Non-insulin-dependent diabetes mellitus--a collision between thrifty genes and an affluent society.
- A 4-Mb high-density single nucleotide polymorphism-based map around human APOE.
- Idiopathic Epilepsies with a Complex Mode of Inheritance
- Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study.
- A genome-wide search strategy for identifying quantitative trait loci involved in reading and spelling disability (developmental dyslexia)
- Genetic dissection of the syndrome X in the rat.
- NKT lymphocyte ontogeny and function are impaired in low antibody-producer Biozzi mice: gene mapping in the interval-specific congenic strains raised for immunomodulatory genes.
- Molecular linkage studies of bipolar disorders.
- Genetic Dissection of Obesity in Polygenic Animal Models
- Genetics of asthma and atopy
- Transgenic and mutant mice for oxygen free radical studies.
- Genetic analysis of juvenile rheumatoid arthritis: approaches to complex traits.
- Genotyping platforms for mass-throughput genotyping with SNPs, including human genome-wide scans.
- Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12
- Genome-wide association mapping of milk production traits in Braunvieh cattle.
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