Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
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Summary
It is demonstrated that PTP-1B has a major role in modulating both insulin sensitivity and fuel metabolism, thereby establishing it as a potential therapeutic target in the treatment of type 2 diabetes and obesity.
- Type
- letter
- Published
- 1999-03-05
- Cited by
- 2,228
- References
- 18
- OpenAlex
- https://openalex.org/W2123229219
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206576708
Keywords
Insulin resistance, Internal medicine, Endocrinology, Insulin, Protein tyrosine phosphatase
References
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- Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase.
- Insulin action impaired by deficiency of the G-protein subunit Giα2
- Protection from obesity-induced insulin resistance in mice lacking TNF-α function
- Expression of protein‐tyrosine phosphatases in the major insulin target tissues
- Receptor-like Protein-tyrosine Phosphatase α Specifically Inhibits Insulin-increased Prolactin Gene Expression*
- Thiazolidine Derivatives Ameliorate High Glucose-induced Insulin Resistance via the Normalization of Protein-tyrosine Phosphatase Activities (*)
- Protein Tyrosine Phosphatase 1B Interacts With the Activated Insulin Receptor
- Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.
- Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
- Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate*
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
- LMW-PTP is a negative regulator of insulin-mediated mitotic and metabolic signalling.
- Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis.
- Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase–deficient Mice
- Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity.
- Protein-Tyrosine Phosphatase 1B Complexes with the Insulin Receptor in Vivo and Is Tyrosine-phosphorylated in the Presence of Insulin*
- Selective Down-regulation of the Insulin Receptor Signal by Protein-tyrosine Phosphatases α and ε (*)
Cited by
- Protein tyrosine phosphatases in human disease.
- A general method for the rapid characterization of tyrosine‐phosphorylated proteins by mini two‐dimensional gel electrophoresis
- Potentiation of Insulin-related Signal Transduction by a Novel Protein-tyrosine Phosphatase Inhibitor, Et-3,4-dephostatin, on Cultured 3T3-L1 Adipocytes*
- Bis(maltolato)oxovanadium(IV) inhibits the activity of PTP1B in Zucker rat skeletal muscle in vivo
- Troglitazone ameliorates abnormal activity of protein tyrosine phosphatase in adipose tissues of Otsuka Long-Evans Tokushima Fatty rats.
- Letter to the Editor: Backbone resonance assignment of the 298 amino acid catalytic domain of protein tyrosine phosphatase 1B (PTP1B)
- A festschrift for Roland L. Weinsier: nutrition scientist, educator, and clinician.
- Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity
- The influence of protein tyrosine phosphatase‐1B on Na,K‐ATPase activity in lens
- Caloric restriction modulates insulin receptor signaling in liver and skeletal muscle of rat.
- Agents in development for the treatment of diabetic nephropathy
- Critical nodes in signalling pathways: insights into insulin action
- Protein tyrosine phosphatases in cancer: friends and foes!
- Improved Glucose Homeostasis in Mice with Muscle-Specific Deletion of Protein-Tyrosine Phosphatase 1B
- Leptin and its metabolic interactions – an update
- Molecular dynamics simulation study of PTP1B with allosteric inhibitor and its application in receptor based pharmacophore modeling
- Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy
- Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models.
- Molecular Mechanism of Insulin Resistance in Obesity and Type 2 Diabetes
- Role of Sirtuin 1 in metabolic regulation.
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