The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
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Summary
The first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules is created, and it is demonstrated that this “Connectivity Map” resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs.
- Type
- article
- Published
- 2006-09-29
- Cited by
- 4,943
- References
- 56
- OpenAlex
- https://openalex.org/W2121604817
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8728079
Keywords
Gene, Computational biology, Drug discovery, Biology, Gene expression
References
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- Selective Estrogen Receptor Modulators
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- PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy?
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- Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.
Cited by
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- Gene expression profiling and its practice in drug development.
- Comparing Genetically Engineered Mouse Mammary Cancer Models with Human Breast Cancer by Expression Profiling
- Gene-expression profiling in epithelial ovarian cancer
- Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors
- Molecular classification and novel targets in hepatocellular carcinoma: recent advancements
- Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice
- Latent Factor Analysis to Discover Pathway-Associated Putative Segmental Aneuploidies in Human Cancers
- The network as the target
- Alignment of gene expression profiles from test samples against a reference database: New method for context-specific interpretation of microarray data
- MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer
- Analyzing Gene Expression Profile in K562 Cells Exposed to Sodium Valproate Using Microarray Combined with the Connectivity Map Database
- Acute myelogenous leukemia stem cells: From Bench to Bedside
- Protein Sets Define Disease States and Predict In Vivo Effects of Drug Treatment*
- Cheminformatics at the interface of medicinal chemistry and proteomics.
- In vitro metabolism and bioavailability tests for endocrine active substances: what is needed next for regulatory purposes?
- Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition
- The Biology of Relapsed Acute Lymphoblastic Leukemia: Opportunities for Therapeutic Interventions
- Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors
- Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
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