Porters versus rowers: a unified stochastic model of motor proteins
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Summary
A general phenomenological theory for chemical to mechanical energy transduction by motor enzymes which is based on the classical "tight-coupling" mechanism is presented, which explains in a unified way many results of recent in vitro motility assays.
- Type
- article
- Published
- 1993-06-02
- Cited by
- 213
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2121141482
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11952796
Keywords
Biology, ATP hydrolysis, Motor protein, Dynein, Motility
References
- Movement of microtubules by single kinesin molecules
- Rotation and translocation of microtubules in vitro induced by dyneins from Tetrahymena cilia.
- Proposed Mechanism of Force Generation in Striated Muscle
- Enzymes for microtubule-dependent motility.
- Muscles, Reflexes, and Locomotion
- Muscle structure and theories of contraction.
- Free Energy Transduction and Biochemical Cycle Kinetics
- Myosin step size. Estimation from slow sliding movement of actin over low densities of heavy meromyosin.
- Sliding filaments and molecular motile systems.
- The myosin step size: measurement of the unit displacement per ATP hydrolyzed in an in vitro assay.
- Kinesin ATPase: rate-limiting ADP release.
- Protein motors and Maxwell's demons: does mechanochemical transduction involve a thermal ratchet?
- The myosin crossbridge problem.
- Sub-piconewton force fluctuations of actomyosin in vitro
- Chemomechanical cycle of kinesin differs from that of myosin
- Bovine brain kinesin is a microtubule-activated ATPase.
- Motor molecules in motion
- Atomic model of the actin filament
- Mechanism of adenosine triphosphate hydrolysis by actomyosin.
- Fluorescent actin filaments move on myosin fixed to a glass surface.
Cited by
- Gas-phase spectroscopy of biomolecular building blocks.
- Power-stroke-driven actomyosin contractility.
- Optical control of fast and processive engineered myosins in vitro and in living cells
- Motility assays of calcium regulation of actin filaments.
- Studies of Synthetic Molecular Motors
- Propriétés mécaniques de touffes ciliaires actives
- Cell Mechanics and Cellular Engineering
- Torque-generating units of the flagellar motor of Escherichia coli have a high duty ratio
- Single kinesin molecules studied with a molecular force clamp
- Novel ways to unravel the mechanism of kinesin
- The structure of microtubule motor proteins.
- Optical trapping, biomolecules and cooperativity
- Dynamics of Intracellular Nano-Transport by Kinesins
- Molecular motors: structural adaptations to cellular functions
- Machines of life: catalogue, stochastic process modeling, probabilistic reverse engineering and the PIs- from Aristotle to Alberts
- Models of protein linear molecular motors for dynamic nanodevices.
- Tau Proteins Harboring Neurodegeneration-Linked Mutations Impair Kinesin Translocation in vitro
- Structural Studies on Kinesin-1 Motor Domain and Light Chain from Rattus norvegicus and Neurospora crassa
- Kinesin hydrolyses one ATP per 8-nm step
- Paradoxical games and Brownian thermal engines
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