On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?
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Summary
Adult thymectomized, irradiated and bone marrow reconstituted mice, transplanted with an irradiated thymus of A origin, generate virus-specific cytotoxic T cells specific for infected A targets but not for B targets; this result formally demonstrates the crucial role of thymic epithelial cells in the differentiation of anti-self-H-2 specificities of T cells.
- Type
- article
- Published
- 1978-03-01
- Cited by
- 859
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2120370266
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5681998
Keywords
Cytotoxic T cell, Biology, Bone marrow, Spleen, Antigen
References
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- Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis
- H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T- cell specificities are associated with structures coded for in H-2K or H-2D;
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- In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells
- Similarity of Idiotypic Determinants of T‐ and B‐Lymphocyte Receptors for Alloantigens
- Rationale for combined use of fetal liver and thymus for immunological reconstitution in patients with variants of severe combined immunodeficiency.
- Y-antigen killing by T cells of women is restricted by HLA
- Two Different VH Gene Products Make Up the T‐Cell Receptors
- The Thymus and the Cellular Basis of Immunity
- FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES
- Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes
- Editorial: Defective thymus development: a cause of combined immunodeficiency.
- Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells
- Role of the Murine Major Histocompatibility Complex in the Specificity of in vitro T‐Cell‐Mediated Lympholysis Against Chemically‐Modified Autologous Lymphocytes
Cited by
- T cells recognize minor histocompatibility antigens on H-2 allogeneic cells
- ROLE OF A CIRCULATING THYMIC FACTOR IN SELF‐RECOGNITION AND SELF‐TOLERANCE *
- T cell mediated cytotoxic immune reactivity of bone marrow reconstituted chimeric mice.
- Interactions of bone marrow cells from young and old mice with syngeneic and allogeneic thymic tissue.
- The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones.
- Analyses of H-2 restriction specificity of helper T cells in fully allogeneic bone marrow chimera in mice.
- Contrasting feature in the repopulation of host-type T cells in the spleens of F1----P and P----F1 radiation bone marrow chimeras.
- Antigen recognition by H-2-restricted cytolytic T lymphocytes is not mediated by two independent receptors
- A third type of murine T-cell receptor gene
- Neoplasms of immunoregulatory T cells in clinical investigation.
- MHC restriction, self-tolerance and the thymus
- Ultrastructure of the rat thymus: The micro-environment of T-lymphocyte maturation
- Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-ficoll. Adaptive differentiation and self- recognition by B cells
- αβTCR+ Cells Are a Minimal Fraction of Peripheral CD8+ Pool in MHC Class I-Deficient Mice1
- Development and selection of T cells: facts and puzzles.
- Positive and negative selection in Basel
- The development of functionally responsive T cells.
- Changes in the human thymus during aging.
- Fine specificity of auto- and alloreactive cytotoxic T-lymphocytes: heteroclitic cross-reactions between mutant and original H-2 antigens.
- Positive-selection-inducing self-peptides displayed by cortical thymic epithelial cells.
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