On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

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Summary

Adult thymectomized, irradiated and bone marrow reconstituted mice, transplanted with an irradiated thymus of A origin, generate virus-specific cytotoxic T cells specific for infected A targets but not for B targets; this result formally demonstrates the crucial role of thymic epithelial cells in the differentiation of anti-self-H-2 specificities of T cells.

Type
article
Published
1978-03-01
Cited by
859
References
38
Access
Open access

Keywords

Cytotoxic T cell, Biology, Bone marrow, Spleen, Antigen

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