The Wnt signaling pathway in development and disease.
Explore this paper's citation graph
Summary
The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
- Type
- review
- Published
- 2004-10-08
- Cited by
- 5,504
- References
- 235
- Access
- Open access
- OpenAlex
- https://openalex.org/W2119284420
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14868306
Keywords
Wnt signaling pathway, Biology, Cell biology, LRP6, Signal transduction
References
- Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.
- Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.
- Female development in mammals is regulated by Wnt-4 signalling
- Frizzled-3 Is Required for the Development of Major Fiber Tracts in the Rostral CNS
- The Hedgehog and Wnt signalling pathways in cancer
- arrow encodes an LDL-receptor-related protein essential for Wingless signalling
- Repressor activity of Headless/Tcf3 is essential for vertebrate head formation
- A Conceptual History of Modern Embryology
- Adherens junctions and β-catenin-mediated cell signalling in a non-metazoan organism
- A transcriptional response to Wnt protein in human embryonic carcinoma cells
- Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling
- Requirement for Wnt3 in vertebrate axis formation
- PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling
- Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
- Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs.
- Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
- The Derailed Guidance Receptor Does Not Require Kinase Activity In Vivo
- Frizzled6 controls hair patterning in mice.
- LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
- An LDL-receptor-related protein mediates Wnt signalling in mice
Cited by
- Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation
- CHARACTERIZATION OF HAM-1 IN THE ASYMMETRIC DIVISION OF C. ELEGANS NEUROBLASTS
- Skeletal development--Wnts are in control.
- FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer
- Advances in Cancer Stem Cell Biology
- The Wnt antagonist secreted frizzled‐related protein‐1 controls osteoblast and osteocyte apoptosis
- In vivo tracing of canonical Wnt signaling in Xenopus tadpoles by means of an inducible transgenic reporter tool
- Expression of beta-catenin is necessary for physiological growth of adult skeletal muscle.
- The emerging complexity of the vertebrate cilium: new functional roles for an ancient organelle.
- Anti‐adipogenic regulation underlies hepatic stellate cell transdifferentiation
- Two Oppositely Localised Frizzled RNAs as Axis Determinants in a Cnidarian Embryo
- CBP/p300 are bimodal regulators of Wnt signaling
- The Arabidopsis thaliana GSK3/Shaggy like kinase AtSK3-2 modulates floral cell expansion
- Wnt1 and Wnt5a affect endothelial proliferation and capillary length; Wnt2 does not
- Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways
- Morphogens and the Control of Cell Proliferation and Patterning in the Spinal Cord
- Synapse specificity: Wnts keep motor axons on target.
- Regulation of osteogenic differentiation during skeletal development.
- Wnt and hedgehog signaling pathways in bone development.
- Seminiferous Tubule Degeneration and Infertility in Mice with Sustained Activation of WNT/CTNNB1 Signaling in Sertoli Cells1
Related papers
- Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina
- Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6.
- Both LRP5 and LRP6 Receptors Are Required to Respond to Physiological Wnt Ligands in Mammary Epithelial Cells and Fibroblasts*
- LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
- High-throughput Analysis of WNT Signaling Pathway in Osteoblasts
- A Novel Set of Wnt-Frizzled Fusion Proteins Identifies Receptor Components That Activate β-Catenin-dependent Signaling*
- Wnt signaling in bone metabolism