The support of human genetic evidence for approved drug indications

Keywords

Drug development, Drug, Biology, Disease, Mechanism (biology)

References

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Cited by

• Purine transport in plasmodium falciparumNeils Benjamin Quashie — 2008
• Влияние философии естественного права и теории общественного договора на становление понятия конституционализма (из истории политической и правовой мысли)Царьков Игорь Иванович — 2012
• Investigation of Effectiveness of Carbonized Rice Husk in Oily Water TreatmentWaj Anurangi, Bmwpk Amarasinghe, Aap De Alwis — 2013
• Identification of drug candidates and repurposing opportunities through compound–target interaction networksAnna Cichońska, Juho Rousu, Tero Aittokallio — 2015
• Deciphering the Causal Role of sPLA2s and Lp-PLA2 in Coronary Heart DiseasePhilippa J. Talmud, Michael V. Holmes — 2015
• GWASdb v2: an update database for human genetic variants identified by genome-wide association studiesMulin Jun Li, Zipeng Liu, Panwen Wang — 2015
• Leveraging Big Data to Transform Target Selection and Drug DiscoveryBin Chen, AJ Butte — 2016
• Protective alleles and modifier variants in human health and diseaseAndrew R. Harper, Shalini Nayee, Eric J. Topol — 2015
• Target validation: Genetic information adds supporting weightMegan Cully — 2015
• Pharmacogenomics to Revive Drug Development in Cardiovascular DiseaseMarie‐Pierre Dubé, Simon de Denus, Jean‐Claude Tardif — 2016
• Using human genetics to make new medicinesJeffrey C. Barrett, Ian Dunham, Ewan Birney — 2015
• Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure responseMohamed H. Shahin, Julie A. Johnson — 2016
• Hunting the genes in male‐pattern alopecia: how important are they, how close are we and what will they tell us?Stefanie Heilmann‐Heimbach, Lara M. Hochfeld, Ralf Paus — 2016
• Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic riskVinicius Tragante, Folkert W. Asselbergs, Daniel I. Swerdlow — 2016
• Health and population effects of rare gene knockouts in adult humans with related parentsVagheesh M. Narasimhan, Karen A. Hunt, Dan Mason — 2015
• Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studiesPhilip Haycock, Stephen Burgess, Kaitlin H. Wade — 2016
• The genetics of drug efficacy: opportunities and challengesMatthew R. Nelson, Toby Johnson, Liling Warren — 2016
• Advances in Understanding Erythropoiesis: Evolving PerspectivesSatish K. Nandakumar, Jacob C. Ulirsch, Vijay G. Sankaran — 2016
• Genetics-directed drug discovery for combating Mycobacterium tuberculosis infectionYuan Quan, Le Xiong, Jing Chen — 2017
• Significant impact of miRNA–target gene networks on genetics of human complex traitsYukinori Okada, Tomoki Muramatsu, Naomasa Suita — 2016

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