Classifying the estrogen receptor status of breast cancers by expression profiles reveals a poor prognosis subpopulation exhibiting high expression of the ERBB2 receptor.
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Summary
It is proposed that a significant portion of ERBB2's effects on ER+ breast tumors may involve ER-independent mechanisms of gene activation, which may contribute to the clinically aggressive behavior of the 'low-confidence' breast tumor subtype.
- Type
- article
- Published
- 2003-12-15
- Cited by
- 51
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W2117495488
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14709300
Keywords
Estrogen receptor, Breast cancer, Confidence interval, Biology, Estrogen
References
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Cited by
- A risk stratification by hormonal receptors (ER, PgR) and HER-2 status in small (≤1 cm) invasive breast cancer: who might be possible candidates for adjuvant treatment?
- Overcoming Tamoxifen Resistance: a Primer for “Regulation of ERBB2 by Oestrogen Receptor-PAX2 Determines Response to Tamoxifen”
- Evaluation of the progesterone receptor status in breast cancer using three different antibodies: a comparison by Allred score system.
- Genomics-based prognosis and therapeutic prediction in breast cancer.
- Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors
- Clinicopathological features of the triple-negative tumors in Chinese breast cancer patients
- In Silico discovery of transcription factors as potential diagnostic biomarkers of ovarian cancer
- The impact of method of biopsy on the incidence of breast cancer sentinel lymph node metastases.
- Estradiol regulates different genes in human breast tumor xenografts compared with the identical cells in culture.
- Cross-talk between ER and HER2 in breast carcinoma
- Endonuclease G promotes cell death of non-invasive human breast cancer cells.
- ERBB2 regulation by Estrogen Receptor-Pax2 determines tamoxifen response
- Clinical significance of HER2-positive and triple-negative status in small (≤ 1 cm) node-negative breast cancer.
- Estrogen Receptor Silencing Induces Epithelial to Mesenchymal Transition in Human Breast Cancer Cells
- Adenosine A1 receptor, a target and regulator of ERα action, mediates the proliferative effects of estradiol in breast cancer
- HER2 status in hormone receptor positive premenopausal primary breast cancer adds prognostic, but not tamoxifen treatment predictive, information
- Patterns of relapse and metastatic spread in HER2-overexpressing breast cancer according to estrogen receptor status
- Hormone receptor expression in uterine sarcomas: prognostic and therapeutic roles.
- Prognostic role of human epidermal growth factor receptor 2 status in premenopausal early breast cancer treated with adjuvant tamoxifen.
- A Machine Learned Classifier That Uses Gene Expression Data to Accurately Predict Estrogen Receptor Status
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