Rac Activation Is Associated with Hepatocellular Carcinoma Metastasis by Up-regulation of Vascular Endothelial Growth Factor Expression
Explore this paper's citation graph
Summary
Rac is a novel angiogenic factor for HCC through the enhancement of HIF-1α protein stability, which provides a possible therapeutic target in the development of inhibitors of angiogenesis.
- Type
- article
- Published
- 2006-09-01
- Cited by
- 51
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2116227441
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6536109
Keywords
Angiogenesis, Metastasis, Cancer research, Vascular endothelial growth factor, Hepatocellular carcinoma
References
- Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97.
- Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide.
- Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA. Vol. 278 (2003) 50702-50713
- Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
- Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.
- Association of Vimentin overexpression and hepatocellular carcinoma metastasis
- Vascular endothelial growth factor–regulated ovarian cancer invasion and migration involves expression and activation of matrix metalloproteinases
- Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α
- Rho family GTPases regulate VEGF-stimulated endothelial cell motility.
- The VHL protein recruits a novel KRAB‐A domain protein to repress HIF‐1α transcriptional activity
- Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma.
- Insulin induces transcription of target genes through the hypoxia‐inducible factor HIF‐1α/ARNT
- Rac Affects Invasion of Human Renal Cell Carcinomas by Up-regulating Tissue Inhibitor of Metalloproteinases (TIMP)-1 and TIMP-2 Expression*
- Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling*
- Rac Regulates Vascular Endothelial Growth Factor Stimulated Motility
- Hepatitis B viral HBx induces matrix metalloproteinase‐9 gene expression through activation of ERKs and PI‐3K/AKT pathways: Involvement of invasive potential
- Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma.
- The risk of liver and bile duct cancer in patients with chronic viral hepatitis, alcoholism, or cirrhosis
- Rho GTPases and signaling networks.
Cited by
- Role of Ras‐related C3 botulinum toxin substrate 2 (Rac2), NADPH oxidase and reactive oxygen species in diallyl disulphide‐induced apoptosis of human leukaemia HL‐60 cells
- Bisphosphonate Inhibition of Prostate Cancer Cell Invasion, Migration and Cytoskeletal Organization
- Implication des voies de signalisation de l'adhérence cellulaire dans le contrôle de l'hypoxie tumorale des glioblastomes
- Efecto de la interacción hormona tiroidea-óxido nítrico y del estrés oxidativo sobre el crecimiento tumoral, la angiogénesis y la actividad aminopeptidásica en tumores desarrollados en ratones
- Hypoxia as a target for drug combination therapy of liver cancer
- Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells
- MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization.
- Synergistic control of cell adhesion by integrins and syndecans
- Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model
- GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis
- Transcriptional regulators in hepatocarcinogenesis--key integrators of malignant transformation.
- Expression of Rac1, HIF-1α, and VEGF in Gastric Carcinoma: Correlation with Angiogenesis and Prognosis
- Rho GTPases modulate malignant transformation of tumor cells
- Hypoxia and hepatocellular carcinoma: The therapeutic target for hepatocellular carcinoma
- Rho GTPases in hepatocellular carcinoma.
- Targeting vessels to treat hepatocellular carcinoma.
- RhoGTPases and Rho‐effectors in hepatocellular carcinoma metastasis: ROCK N' Rho move it
- Expression of hypoxia-inducible factor 1α gene affects the outcome in patients with ovarian cancer
- Involvement of Rac in fenretinide-induced apoptosis.
- Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration
Related papers
- The expression of VEGF、KDR in hepatocellular carcinoma and its modulation by p53 and ras in human
- RUNX3 Inhibits the Expression of Vascular Endothelial Growth Factor and Reduces the Angiogenesis, Growth, and Metastasis of Human Gastric Cancer
- The influence of vascular endothelial growth factor-A and matrix metalloproteinase-2 and -9 in angiogenesis, metastasis, and prognosis of endometrial cancer
- Anti-angiogenic gene therapy of malignant glioma.
- Vascular Endothelial Growth Factor in Human Colon Cancer: Biology and Therapeutic Implications
- Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications.
- The effects of the expression of VEGF and KDR on the angiogenesis,growth and metastasis of hepatocellular carcinoma
- [The effects of the expression of VEGF and KDR on the angiogenesis, growth and metastasis of hepatocellular carcinoma].