Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives
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Summary
Current knowledge on the role of disturbed flow in EC physiology and pathophysiology, as well as its clinical implications are summarized to contribute to the understanding of the etiology of lesion development in vascular niches with disturbed flow and help to generate new approaches for therapeutic interventions.
- Type
- review
- Published
- 2011-01-01
- Cited by
- 2,248
- References
- 673
- Access
- Open access
- OpenAlex
- https://openalex.org/W2115533377
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29939611
Keywords
Pathophysiology, Restenosis, Endothelium, Pathogenesis, Hemodynamics
References
- Pathogenesis of atherosclerosis.
- Wall shear stress temporal gradient and anastomotic intimal hyperplasia.
- Helical and Retrograde Secondary Flow Patterns in the Aortic Arch Studied by Three‐Directional Magnetic Resonance Velocity Mapping
- Bone morphogenetic protein expression in human atherosclerotic lesions.
- Tumor Necrosis Factor α-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways*
- Modulation of Arterial Growth of the Rabbit Carotid Artery Associated with Experimental Elevation of Blood Flow
- Atherosclerosis--an inflammatory disease.
- Expression of endothelial cell adhesion molecules on heart valves: up‐regulation in degeneration as well as acute endocarditis
- Mechanism of temporal gradients in shear-induced ERK1/2 activation and proliferation in endothelial cells.
- Beneficial effects of antioxidants and l-arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress
- Venous hypertension, inflammation and valve remodeling.
- Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents.
- The Role of the Multidrug Resistance Protein-1 in Modulation of Endothelial Cell Oxidative Stress
- A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
- Differences in Vascular Bed Disease Susceptibility Reflect Differences in Gene Expression Response to Atherogenic Stimuli
- Mechanisms of mechanotransduction.
- Regulation of Endothelial Cell Cycle by Laminar Versus Oscillatory Flow: Distinct Modes of Interactions of AMP-Activated Protein Kinase and Akt Pathways
- Role of the endothelium and blood stasis in the development of varicose veins.
- Increased mast cell infiltration in familial varicose veins: pathogenetic implications?
- Pathological findings at bifurcation lesions: the impact of flow distribution on atherosclerosis and arterial healing after stent implantation.
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- Mechanosensing in developing lymphatic vessels.
- Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.
- Simulation numérique des interactions fluide-structure dans une fistule artério-veineuse sténosée et des effets de traitements endovasculaires
- Simulated hemodynamics in human carotid bifurcation based on Doppler ultrasound data
- The role of the haemodynamic Palladin protein within the Vasculature
- Fibrinogen as a key regulator of inflammation in disease
- Frequent Dilatation of the Descending Aorta in Children With Hypoplastic Left Heart Syndrome Relates to Decreased Aortic Arch Elasticity
- Hemodynamic modeling of leukocyte and erythrocyte transport and interactions in intracranial aneurysms by a multiphase approach.
- In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV
- Coordination of cellular localization-dependent effects of SUMOylation in regulating cardiovascular and neurological diseases
- Numerical simulation of haemodynamics and low-density lipoprotein transport in the rabbit aorta and their correlation with atherosclerotic plaque thickness
- Detection of frequency-dependent endothelial response to oscillatory shear stress using a microfluidic transcellular monitor
- Vascular remodelling in the pulmonary circulation after major lung resection
- Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow
- Microvascular Network and Its Endothelial Cells in the Human Iris
- Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE-/- mice.
- Mechanobiological Feedback in Pulmonary Vascular Disease
- Chronische Entzündung und Atherosklerose
- Perfusion Tissue Culture Initiates Differential Remodeling of Internal Thoracic Arteries, Radial Arteries, and Saphenous Veins
- Long-term performance of an external stent for saphenous vein grafts: the VEST IV trial
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