The potential of aromatase inhibitors in breast cancer prevention.
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Summary
The hypothesis is that breast tissue estrogen levels, as a result of in situ synthesis, are much higher than previously thought and provide a strong rationale for studies of aromatase inhibitors to prevent breast cancer.
- Type
- review
- Published
- 1999-06-01
- Cited by
- 88
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2115001576
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11535676
Keywords
Aromatase, Estrogen, Breast cancer, Internal medicine, Cancer research
References
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- Aromatase expression in health and disease.
- Etiology:Chemical and Physical Carcinogenesis
- Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue.
- Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities.
- Breast cancer and artificial menopause: a cohort study.
- Menopause and breast cancer risk.
- Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial.
- Gene expression screening for specific genes associated with mouse mammary tumor development
- The overexpression of int-5/Aromatase, a novel MMTV integration locus gene, is responsible for D2 mammary tumor cell proliferation.
- Is tamoxifen effective in prevention of breast cancer?
- Epidemiologic evidence for the increased cell proliferation model of carcinogenesis.
- A prospective study of endogenous estrogens and breast cancer in postmenopausal women.
- The importance of local synthesis of estrogen within the breast.
- An aromatase-producing sex-cord tumor resulting in prepubertal gynecomastia.
- Prognostic value of breast cancer aromatase
- Body size in different periods of life and breast cancer risk in post‐menopausal women
- Serum sex hormone levels are related to breast cancer risk in postmenopausal women.
- Stromal spindle cells contain aromatase in human breast tumors.
- Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast.
Cited by
- Gemcitabine plus cisplatin in breast cancer.
- The use of simvastatin with aromasin in an ovariectomized rat model: effects on the skeletal system.
- Power frequency electromagnetic fields, melatonin and the risk of breast cancer.
- Microfluidic biosensing systems based on enzymes, antibodies and cells
- Oestrogen receptor downregulation: an opportunity for extending the window of endocrine therapy in advanced breast cancer.
- Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate.
- Breast cancer chemoprevention: current challenges and a look toward the future.
- 17α-Methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture
- Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation
- Use of biomarkers for breast cancer risk assessment and prevention.
- Biological rationale for endocrine therapy in breast cancer.
- Bioidentical Hormone Therapy: A Review of the Evidence
- Chemoprevention for High‐Risk Women: Tamoxifen and Beyond
- Use of risk determinants for different breast cancer prevention strategies.
- Rapid estradiol/ERalpha signaling enhances aromatase enzymatic activity in breast cancer cells.
- The prevention of breast cancer
- Chemoprevention of Breast Cancer
- Reducing the risk of breast cancer.
- Antiaromatase agents: evolving role in adjuvant therapy.
- Quimioprevención del cáncer de mama
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- Estimation of Breast Density from Human Mammograms using U-Nets
- Activity of aromatase in breast cancer tissue: Role of the cell substrate
- Peroxidase activity in the rat breast tissue as a marker of estrogen action.
- Mammographic breast density as an intermediate phenotype for breast cancer.