Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension *
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Summary
Among elderly patients with isolated systolic hypertension, antihypertensive drug treatment starting with nitrendipine reduces the rate of cardiovascular complications and may prevent 29 strokes or 53 major cardiovascular endpoints.
- Type
- article
- Published
- 1997-09-13
- Cited by
- 2,699
- References
- 50
- OpenAlex
- https://openalex.org/W2114634962
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3918591
Keywords
Medicine, Blood pressure, Placebo, Enalapril, Stroke (engine)
References
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- Treatment of hypertension in the elderly
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- Guidelines for the management of hypertension: the world Health organisation/International society of Hypertension View
- Randomised trial of treatment of hypertension in elderly patients in primary care.
- The pathogenetic role and treatment of elderly hypertension.
- A multiple testing procedure for clinical trials.
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- Antihypertensive therapy in older patients with isolated systolic hypertension: the Syst-Eur experience in general practice
- Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly: Objectives, protocol, and organization
- Implications for trials in progress of publication of positive results.
- Nifedipine. Dose-related increase in mortality in patients with coronary heart disease.
- A case-control study of measles vaccination and inflammatory bowel disease. The East Dorset Gastroenterology Group.
- The risk of myocardial infarction associated with antihypertensive drug therapies.
Cited by
- Aggressive Hypertension Management in Patients of Advancing and Advanced Age
- Acute stroke: evaluation and treatment.
- Effect of Low-Dose Manidipine on Ambulatory Blood Pressure in Very Elderly Hypertensives
- Neue ESH/ESC-Leitlinien für die arterielle Hypertonie
- 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension
- Current recommendations for initial therapy in hypertension: are they still valid? Introduction.
- Systolic blood pressure, isolated systolic hypertension and risk of coronary heart disease, strokes, cardiovascular disease and all‐cause mortality in the middle‐aged population
- Calcium antagonists and the diabetic patient: a response to recent controversies.
- Trends in prescribing calcium-channel blockers
- Joint British recommendations on prevention of coronary heart disease in clinical practice
- Blood pressure and the global burden of cardiovascular disease.
- Cardiovascular health check in the elderly in one general practice: does it offer new information and lead to interventions?
- The role of angiotensin II receptor antagonists in hypertension management: focus on candesartan cilexetil
- Risks of coronary heart disease in women: current understanding and evolving concepts.
- Baseline Characteristics and Early Blood Pressure Control in the CONVINCE Trial
- Treatment Strategy to Control Blood Pressure Optimally in Hypertensive Patients
- The INSIGHT and NORDIL trials: Are calcium antagonists equivalent to established drug therapies for cardiovascular protection?
- Management of High‐Risk Hypertensive Patients with Diabetes: Potential Role of Angiotensin II Receptor Antagonists
- Multifactorial cardiovascular disease prevention in patients aged 75 years and older: A randomized controlled trial: Drugs and Evidence Based Medicine in the Elderly (DEBATE) Study.
- Treatment of hypertension in the elderly.
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