Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group.
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Summary
Treatment with oral conjugated equine estrogen plus medroxyprogesterone acetate did not reduce the overall rate of CHD events in postmenopausal women with established coronary disease and the treatment did increase the rate of thromboembolic events and gallbladder disease.
- Type
- article
- Published
- 1998-08-19
- Cited by
- 6,411
- References
- 59
- OpenAlex
- https://openalex.org/W2113264115
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29298925
Keywords
Medicine, Medroxyprogesterone acetate, Myocardial infarction, Hazard ratio, Internal medicine
References
- Heart and Estrogen/progestin Replacement Study (HERS): design, methods, and baseline characteristics.
- The use of hormonal replacement therapy and the risk of stroke and myocardial infarction in women.
- A case-control study of myocardial infarction in relation to use of estrogen supplements.
- Coronary heart disease and estrogen replacement therapy. Can compliance bias explain the results of observational studies?
- Estrogen replacement and coronary artery disease. Effect on survival in postmenopausal women.
- Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone.
- Estrogen and cardiovascular function after menopause.
- Comparison of the Heart and Estrogen/Progestin Replacement Study (HERS) cohort with women with coronary disease from the National Health and Nutrition Examination Survey III (NHANES III)
- Effects of hormone replacement therapy on reactivity of atherosclerotic coronary arteries in cynomolgus monkeys.
- Prevalence and determinants of estrogen replacement therapy in elderly women
- Relation between estrogen replacement therapy and restenosis after percutaneous coronary interventions.
- The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering.
- Decreased Mortality in Users of Estrogen Replacement Therapy
- A study of the association between hormone replacement therapy, smoking and the occurrence of myocardial infarction in women.
- Risk of hospital admission for idiopathic venous thromboembolism among users of postmenopausal oestrogens.
- Cardiovascular effects of estrogen and lipid-lowering therapies in postmenopausal women.
- The Use of Placebos in Controlled Trials
- Estrogen replacement therapy after coronary angioplasty in women.
- Hormone replacement therapy and risk of venous thromboembolism: population based case-control study
- Prospective study of exogenous hormones and risk of pulmonary embolism in women.
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- Tibolone inhibits aortic atherosclerotic lesionformation in oophorectomized cholesterol-fed rabbits.
- Tratamiento médico de la angina estable: Fármacos antianginosos y prevención secundaria de la cardiopatía isquémica
- Oestrogensubstitutionstherapie und Arteriosklerose - Pathophysiologie und therapeutische Implikationen
- Soy isoflavones reduce heat shock proteins in postmenopausal women
- Pentagastrin-induced release of free fatty acids in healthy volunteers and patients with panic disorder: effect of pretreatment with ethinyl estradiol.
- Therapy for fracture prevention.
- Heart disease linked to oestrogen-receptor gene methylation.
- Neuroprotective effects of female gonadal steroids in reproductively senescent female rats.
- Selective estrogen receptor modulators—A new age of estrogens in cardiovascular disease?
- Current concepts in secondary prevention after acute myocardial infarction
- Normal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome.
- Risks of coronary heart disease in women: current understanding and evolving concepts.
- Interaction of estrogen replacement therapy with the thrombophilic 20210 G/A prothrombin gene mutation for atherothrombotic vascular disease: a cross-sectional study of 275 hyperlipidemic women.
- Effects of hormone replacement on hemostasis in spontaneous menopause
- A systematic review of randomized trials of disease management programs in heart failure.
- Beyond the cholesterol profile: Monitoring therapeutic effectiveness of statin therapy
- Hormone replacement therapy and acquired resistance to activated protein C: results of a randomized, double‐blind, placebo‐controlled trial
- Effect of Medroxyprogesterone Acetate on Vascular Inflammatory Markers in Postmenopausal Women Receiving Estrogen
- Lassen sich die Akuteffekte transdermaler Östradiolgabe bei Patientinnen mit koronarer Herzerkrankung durch Änderungen des autonomen Tonus miterklären?
- Aromatase Inhibitors and Inactivators for Breast Cancer Therapy
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