The pathogenesis of rheumatoid arthritis.
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Summary
The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.
- Type
- review
- Published
- 2011-12-07
- Cited by
- 2,744
- References
- 107
- OpenAlex
- https://openalex.org/W2110826367
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17460029
Keywords
Medicine, Rheumatoid arthritis, Natural history, Pathogenesis, Disease
References
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- Chemokines and angiogenesis in rheumatoid arthritis
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- Membrane-Type I Matrix Metalloproteinase-Dependent Regulation of Rheumatoid Arthritis Synoviocyte Function
- Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines.
- Fibroblast-Like Synoviocytes of Mesenchymal Origin Express Functional B Cell-Activating Factor of the TNF Family in Response to Proinflammatory Cytokines1
- Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis.
- Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006
- C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
- Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis.
- Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case-control study in Norfolk, England.
- Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs.
- BLyS and APRIL in rheumatoid arthritis.
- Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue.
- G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis
- Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target
- Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis.
- A function for the QKRAA amino acid motif: mediating binding of DnaJ to DnaK. Implications for the association of rheumatoid arthritis with HLA-DR4.
- Rheumatoid arthritis synovium contains two subsets of CD83-DC-LAMP- dendritic cells with distinct cytokine profiles.
- Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice.
Cited by
- Новые подходы к фармакотерапии ревматоидного артрита: тофацитиниб
- Autoimmunity in rheumatoid arthritis: citrulline immunity and beyond.
- Synthesis and biological evaluation of pyranoisoflavone derivatives as anti-inflammatory agents.
- Cost-utility analysis of tocilizumab monotherapy in first line versus standard of care for the treatment of rheumatoid arthritis in Greece
- Safety and immunogenicity of a novel therapeutic DNA vaccine encoding chicken type II collagen for rheumatoid arthritis in normal rats
- Amelioration of FCA induced arthritis on topical application of curcumin in combination with emu oil.
- The role of female hormonal factors in the development of rheumatoid arthritis
- ER Stress: A Therapeutic Target in Rheumatoid Arthritis?
- Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single‐agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate
- Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?
- 14-3-3η protein: a promising biomarker for rheumatoid arthritis.
- Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis
- Comparison of rheumatoid arthritis (RA) and osteoarthritis (OA) based on microarray profiles of human joint fibroblast‐like synoviocytes
- RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast-like synoviocytes
- Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis
- Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes
- Detection of inflammation from finger temperature profile in rheumatoid arthritis
- Beyond Systemic Lupus Erythematosus and Anti-Phospholipid Syndrome: The Relevance of Complement From Pathogenesis to Pregnancy Outcome in Other Systemic Rheumatologic Diseases
- Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis.
- Sneaking-ligand fusion proteins attenuate serum transfer arthritis by endothelium-targeted NF-κB inhibition.
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