Meta-analysis of BRCA1 and BRCA2 penetrance.
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Summary
A set of risk estimates for BRCa1 and BRCA2 mutation carriers that can be used by counselors and clinicians who are interested in advising patients based on a comprehensive set of studies rather than one specific study are provided.
- Type
- review
- Published
- 2007-04-10
- Cited by
- 1,830
- References
- 19
- Access
- Open access
- OpenAlex
- https://openalex.org/W2110137106
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33003455
Keywords
Penetrance, Medicine, Population, Breast cancer, Oncology
References
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- Average age-specific cumulative risk of breast cancer according to type and site of germline mutations in BRCA1 and BRCA2 estimated from multiple-case breast cancer families attending Australian family cancer clinics
- Autosomal dominant inheritance of early‐onset breast cancer. Implications for risk prediction
- Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2.
- The BOADICEA model of genetic susceptibility to breast and ovarian cancer
- Penetrances of breast and ovarian cancer in a large series of families tested for BRCA1/2 mutations
- Unusual case of Smith-Lemli-Opitz syndrome "type II".
- Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2
- Characterization of BRCA1 and BRCA2 mutations in a large United States sample.
- Meta-analysis in clinical trials.
- Application of breast cancer risk prediction models in clinical practice.
- Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies
- Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
- Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations.
- On the use of familial aggregation in population-based case probands for calculating penetrance.
- The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations.
- Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of protein-truncating mutations in BRCA1 and BRCA2. Australian Breast Cancer Family Study.
- The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
- BayesMendel: an R Environment for Mendelian Risk Prediction
Cited by
- The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets
- Anticipatory Loss and Early Mastectomy for Young Female BRCA1/2 Mutation Carriers
- Early Onset Breast Cancer in a Registry‐based Sample of African‐American Women: BRCA Mutation Prevalence, and Other Personal and System‐level Clinical Characteristics
- 10 rare tumors that warrant a genetics referral
- Management of women at high risk of breast cancer
- The spectrum of BRCA1 and BRCA2 alleles in Latin America and the Caribbean: a clinical perspective
- Impact of Genetic Counseling and Testing on Altruistic Motivations to Test: A Longitudinal Study
- BRCA1 and BRCA2 mutations in ovarian cancer patients from China: ethnic‐related mutations in BRCA1 associated with an increased risk of ovarian cancer
- Prevalence and Penetrance of BRCA1 and BRCA2 Germline Mutations in Colombian Breast Cancer Patients
- Novel loss-of-function mutation in BRCA2 gene identified in a Chinese female with a family history of ovarian cancer: A case report
- Barriers to genetic testing for breast cancer risk among ethnic minority women: an exploratory study.
- Hereditary breast/ovarian cancer syndrome: a primer for obstetricians/gynecologists.
- [Multidisciplinary clinical management for prophylactic mastectomy: views of women from one centre in Quebec City].
- Advanced epithelial ovarian cancer – studies on preoperative [18F] FDG PET/CT and HE4 profile during primary chemotherapy
- [Personalized medicine and breast cancer: anticipatory medicine, prognostic evaluation and therapeutic targeting].
- Perceptions of Breast Cancer-Related Stigma and Genetic Knowledge Among Latina Women: El Mejor Entendimiento Del Miedo.
- Design, Development, and Evaluation of Tools to Study Cellular ADP-ribose Polymer Metabolism
- Critical Analysis of Contemporary Public Health Genomics and Needs Assessment for Public Health Genomics Course Curriculum
- Prognostiska faktorer vid serös ovarialcancer
- [Cognitive, emotional and behavioral impact of an uncertain outcome after study of BRCA1/2: review of the literature].
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