Sequence and organization of the human mitochondrial genome
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Summary
The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
- Type
- article
- Published
- 1981-04-09
- Cited by
- 9,496
- References
- 59
- OpenAlex
- https://openalex.org/W2109291482
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4355527
Keywords
Mitochondrial DNA, Gene, Genetics, Polyadenylation, Biology
References
- Mapping of nascent light and heavy strand transcripts on the physical map of HeLa cell mitochondrial DNA.
- The transcription map of human mitochondrial DNA implicates transfer RNA excision as a major processing event.
- Assembly of the mitochondrial membrane system. The DNA sequence of a mitochondrial ATPase gene in Saccharomyces cerevisiae.
- Purification and properties of a specific Escherichia coli ribonuclease which cleaves a tyrosine transfer ribonucleic acid presursor.
- Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA.
- Assembly of the mitochondrial membrane system. DNA sequence and organization of the cytochrome b gene in Saccharomyces cerevisiae D273-10B.
- A mammalian mitochondrial serine transfer RNA lacking the "dihydrouridine" loop and stem.
- Mapping of mitochondrial DNA of individual sheep and goats: rapid evolution in the D loop region.
- Cloning of human mitochondrial DNA in Escherichia coli.
- Assembly of the mitochondrial membrane system: sequences of yeast mitochondrial valine and an unusual threonine tRNA gene.
- The tRNA genes punctuate the reading of genetic information in human mitochondrial DNA.
- Tyrosine tRNA precursor molecule polynucleotide sequence.
- Distinctive features of the 5′-terminal sequences of the human mitochondrial mRNAs
- The 3'-terminal sequence of the small subunit ribosomal RNA from hamster mitochondria.
- "Two out of three": an alternative method for codon reading.
- The mitochondrial genome of yeast.
- Initiator tRNAs have a unique anticodon loop conformation.
- Sequence data handling by computer.
- Structure and function of mitochondrial DNA
- Mechanism of mitochondrial DNA replication in mouse L-cells: kinetics of synthesis and turnover of the initiation sequence.
Cited by
- Mitochondrial DNA Mutations and Pathogenesis
- Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer's disease.
- Mitochondrial DNA and genetic disease
- Mitochondrial encephalomyopathies with the mutation of the mitochondrial tRNA(Leu(UUR)) gene.
- Evolution of ecological differences in the Old World leaf warblers
- Sensorineural deafness inherited as a tissue specific mitochondrial disorder.
- Mitochondrial DNA topoisomerase I from human platelets.
- What is the essential proton-translocating molecular machinery in cytochrome oxidase?
- A defect in mitochondrial electron-transport activity (NADH-coenzyme Q oxidoreductase) in Leber's hereditary optic neuropathy.
- The fingernails of Mary Sullivan: developing reliable methods for selectively isolating endogenous and exogenous DNA from evidence.
- Restriction enzyme analysis of the mitochondrial genome in mitochondrial myopathy.
- Animal mitochondrial DNA: an extreme example of genetic economy.
- Co‐evolution of base composition and codon usage in Xenopus laevis and human globin genes with long‐range DNA organization of their genome
- The excised leader of human cytochrome c oxidase subunit I mRNA which contains the origin of mitochondrial DNA light-strand synthesis accumulates in mitochondria and is polyadenylated.
- Identification of the polypeptide encoded by the URF-1 gene of Neurospora crassa mtDNA.
- Distribution of “Mongoloid” Haplogroups of Mitochondrial DNA Among Indigenous Population of the Tuva Republic
- Translational interference at overlapping reading frames in prokaryotic messenger RNA.
- Mitochondrial DNA in the Central European population. Human identification with the help of the forensic mt-DNA D-loop-base database.
- Mitochondrial genomes of the ciliates.
- Ancient Mitochondrial DNA From Pre-historic Southeastern Europe: The Presence of East Eurasian Haplogroups Provides Evidence of Interactions with South Siberians Across the Central Asian Steppe Belt
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