Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations.
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Summary
The majority of the aggregation is due to adsorption at air-liquid and solid-air interfaces formed during spray-lyophilization or lyophilized samples, but subsequent drying and reconstitution caused aggregation.
- Type
- article
- Published
- 2002-06-01
- Cited by
- 120
- References
- 32
- OpenAlex
- https://openalex.org/W2106743573
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31721616
Keywords
Chemistry, Freeze-drying, Adsorption, Chromatography, Polyvinyl alcohol
References
- Surface Denaturation at Solid-Void Interface—A Possible Pathway by Which Opalescent Participates Form During the Storage of Lyophilized Tissue-Type Plasminogen Activator at High Temperatures
- Proteins at liquid interfaces
- Methods for studying protein adsorption.
- Type I 'antifreeze' proteins. Structure-activity studies and mechanisms of ice growth inhibition.
- Surface characterisation of freeze-dried protein/carbohydrate mixtures.
- The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf.
- Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation.
- Orogenic Displacement of Protein from the Air/Water Interface by Competitive Adsorption.
- Characterisation of the initial period of protein adsorption by dynamic surface tension measurements using different drop techniques
- Dynamics of protein and mixed protein/surfactant adsorption layers at the water/fluid interface.
- Equation of State for Concentrated Protein Surface Layers at the Water/Air Interface
- Determination of residual moisture in freeze-dried viral vaccines: Karl Fischer gravimetric and thermogravimetric methodologies.
- Proteins in frozen solutions: evidence of ice-induced partial unfolding.
- ADSORPTION OF GASES IN MULTIMOLECULAR LAYERS
- Stability and surface activity of lactate dehydrogenase in spray-dried trehalose.
- Antifreeze Proteins: Structures and Mechanisms of Function.
- Adsorption of protein layers at the water/air interface as studied by axisymmetric drop and bubble shape analysis.
- Generation of Steady Liquid Microthreads and Micron-Sized Monodisperse Sprays in Gas Streams
- Biopharmaceutical powders: particle formation and formulation considerations.
- Surface-induced denaturation of proteins during freezing and its inhibition by surfactants.
Cited by
- Sonochemically born proteinaceous micro- and nanocapsules.
- Insulin-based Nanowire Structures: Production, Characterization and Catalysis Potential.
- Aggregation of therapeutic proteins
- Pharmaceutical process optimisation of bulk lyophilisates:implications of powder handling
- Cyclodextrins as excipients in drying of proteins and controlled ice nucleation in freeze-drying
- Therapeutic Proteins
- Micronization of Proteins by Jet Milling
- Evaluation of nano spray drying as a method for drying and formulation of therapeutic peptides and proteins
- Spray freezing into liquid to produce protein microparticles
- Formation of Stable Submicron Protein Particles by Thin Film Freezing
- Investigation of processing parameters of spray freezing into liquid to prepare polyethylene glycol polymeric particles for drug delivery
- Protein Quantity on the Air-Solid Interface Determines Degradation Rates of Human Growth Hormone in Lyophilized Samples
- Spray-freeze-drying: A novel process for the drying of foods and bioproducts
- Melittin-lipid bilayer interactions and the role of cholesterol.
- A Method of Lyophilizing Vaccines Containing Aluminum Salts into a Dry Powder Without Causing Particle Aggregation or Decreasing the Immunogenicity Following Reconstitution
- Next generation drying technologies for pharmaceutical applications.
- Inhaled proteins: challenges and perspectives.
- Influence of Protein Conformation and Adjuvant Aggregation on the Effectiveness of Aluminum Hydroxide Adjuvant in a Model Alkaline Phosphatase Vaccine
- Principles, approaches, and challenges for predicting protein aggregation rates and shelf life.
- Templated Open Flocs of Nanorods for Enhanced Pulmonary Delivery with Pressurized Metered Dose Inhalers
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