Molecular properties that influence the oral bioavailability of drug candidates.
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Summary
Reduced molecular flexibility, as measured by the number of rotatable bonds, and low polar surface area or total hydrogen bond count are found to be important predictors of good oral bioavailability, independent of molecular weight.
- Type
- article
- Published
- 2002-05-11
- Cited by
- 7,481
- References
- 38
- OpenAlex
- https://openalex.org/W2105649494
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16470979
Keywords
Bioavailability, Chemistry, Polar surface area, Lipophilicity, Permeation
References
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- High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid Solution Used in Parallel Artificial Membrane Permeation Assay
- Structure and electrochemical properties of microfiltration filter-lipid membrane systems
- Design principles for orally bioavailable drugs
- Pharmacokinetic and Pharmacodynamic Implications of P‐glycoprotein Modulation
- Drug-like properties and the causes of poor solubility and poor permeability.
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- How structural features influence the biomembrane permeability of peptides.
- Strategies toward predicting peptide cellular permeability from computed molecular descriptors.
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