PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.
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Summary
The study demonstrates that the in vivo neurochemical phenotype of LRRK2 mutations is indistinguishable from that of sPD, despite the pathological heterogeneity of the condition, and suggests that compensatory changes including downregulation of the DAT and upregulation of decarboxylase activity may delay the onset of parkinsonian symptoms.
- Type
- article
- Published
- 2005-12-01
- Cited by
- 267
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2101443804
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14147598
Keywords
Dopamine transporter, LRRK2, Dopaminergic, Vesicular monoamine transporter, Parkinsonism
References
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- Genetic clues to the pathogenesis of Parkinson's disease
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- A proof of principle for targetry to produce ultra high quantities of 18F-fluoride.
- An 18O2 target for the production of [18F]F2
Cited by
- The importance of LRRK2 mutations in Parkinson disease.
- When does Parkinson's disease begin?
- Manganese Homeostasis and Transport
- The Nature of Progression in Parkinson’s Disease: An Application of Non-Linear, Multivariate, Longitudinal Random Effects Modelling
- Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice
- In vivo imaging of synaptic function in the central nervous system: I. Movement disorders and dementia.
- Dopamine: PET Imaging and Parkinson Disease.
- Hereditary early-onset Parkinsonism : the role of the FBXO7 protein
- Cerebral reorganization in premotor parkinsonism
- G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system
- Altered motor phenotype and dopamine transmission associated with mutations of the parkinsonian gene LRRK2
- Biomarkers for trials of neuroprotection in Parkinson's disease
- Nuklearmedizinisches Imaging bei Parkinson-Syndromen
- Weighted registration of 123I‐FP‐CIT SPECT images improves accuracy of binding potential estimates in pathologically low striatal uptake
- Optimizing diagnosis in Parkinson's disease: Radionuclide imaging.
- Clinical and pathologic features of families with LRRK2-associated Parkinson's disease.
- LRRK2 in Parkinson’s disease: genetic and clinical studies from patients
- Neurobildgebung genetischer Aspekte der Parkinson-Krankheit
- Positron emission tomography neuroimaging in Parkinson's disease.
- Behavioral Deficits and Striatal DA Signaling in LRRK2 p.G2019S Transgenic Rats: A Multimodal Investigation Including PET Neuroimaging
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