PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.

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Summary

The study demonstrates that the in vivo neurochemical phenotype of LRRK2 mutations is indistinguishable from that of sPD, despite the pathological heterogeneity of the condition, and suggests that compensatory changes including downregulation of the DAT and upregulation of decarboxylase activity may delay the onset of parkinsonian symptoms.

Type
article
Published
2005-12-01
Cited by
267
References
56
Access
Open access

Keywords

Dopamine transporter, LRRK2, Dopaminergic, Vesicular monoamine transporter, Parkinsonism

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