Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators.
Explore this paper's citation graph
Summary
Despite the increased risk of intracranial haemorrhage, thrombolysis with alteplase at a dose of 0.9 mg/kg in selected patients may lead to a clinically relevant improvement in outcome.
- Type
- article
- Published
- 1998-10-17
- Cited by
- 3,654
- References
- 21
- OpenAlex
- https://openalex.org/W2098032054
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53549605
Keywords
Medicine, Placebo, Thrombolysis, Modified Rankin Scale, Internal medicine
References
- Acute human stroke studied by whole brain echo planar diffusion‐weighted magnetic resonance imaging
- A systems approach to immediate evaluation and management of hyperacute stroke. Experience at eight centers and implications for community practice and patient care. The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group.
- Streptokinase for acute ischemic stroke with relationship to time of administration: Australian Streptokinase (ASK) Trial Study Group.
- Stroke units versus general medical wards, I: twelve- and eighteen-month survival: a randomized, controlled trial.
- Acute stroke: usefulness of early CT findings before thrombolytic therapy.
- Tissue-plasminogen activator for acute ischaemic stroke (multiple letters) [4]
- Stroke unit versus general medical wards, II: neurological deficits and activities of daily living: a quasi-randomized controlled trial.
- The ECASS 3-hour cohort. Secondary analysis of ECASS data by time stratification. ECASS Study Group. European Cooperative Acute Stroke Study.
- Dichotomized efficacy end points and global end-point analysis applied to the ECASS intention-to-treat data set: post hoc analysis of ECASS I.
- Hemorrhagic cerebral infarction--a prospective study.
- Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)
- Hemorrhagic transformation in cerebral embolism.
- Evolving stroke and the ischemic penumbra
- Variables associated with hospital arrival time after stroke: effect of delay on the clinical efficiency of early treatment.
- Thrombolytic therapy with streptokinase in acute ischemic stroke.
- Collaborative systematic review of the randomised trials of organised inpatient (stroke unit) care after stroke
- Treatment of acute ischemic stroke. Challenging the concept of a rigid and universal time window.
Cited by
- Der akute ischämische Schlaganfall
- ASPECTS-DWIにおける領域別早期虚血変化とrt-PA静注療法後の脳梗塞患者の転帰
- Acute stroke: evaluation and treatment.
- Thrombolysis in the Treatment of Acute Ischaemic Stroke
- Endovaskuläre Therapie des akut ischämischen Schlaganfalls unter Analgosedierung im Vergleich zur Intubationsnarkose – Durchführbarkeit, periprozedurale Sicherheit, klinisches und radiologisches Outcome
- Antithrombotic Therapy for Prevention and Treatment of Ischemic Stroke
- PROGNOSTIC VALUE OF CT SCAN FEATURES IN ACUTE ISCHAEMIC STROKE AND RELATIONSHIP WITH CLINICAL STROKE SYNDROMES
- Vermeidung von Zeitverzögerungen im Management akuter Schlaganfallpatienten. Analyse des österreichischen Stroke-Unit-Registers
- ECASS-II: intravenous alteplase in acute ischaemic stroke
- Ischemic Penumbra: Evidence From Functional Imaging in Man
- Patients with acute stroke: Recent developments in neuroimaging
- Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy
- Toward Wisdom From Failure: Lessons From Neuroprotective Stroke Trials and New Therapeutic Directions
- Stroke--acute interventions.
- Prediction of Malignant Middle Cerebral Artery Infarction by Early Perfusion- and Diffusion-Weighted Magnetic Resonance Imaging
- Perfusion thresholds in acute stroke thrombolysis.
- Acute Ischemic Stroke: Time, Penumbra, and Reperfusion
- Effect of Incomplete (Spontaneous and Postthrombolytic) Recanalization After Middle Cerebral Artery Occlusion: A Magnetic Resonance Imaging Study
- Stroke, dementia, and drug delivery.
- Early Fibrinogen Degradation Coagulopathy Is Predictive of Parenchymal Hematomas in Cerebral rt-PA Thrombolysis: A Study of 157 Cases
Related papers
- Thrombolysis Despite Recent Stroke
- Tenecteplase versus alteplase in stroke thrombolysis: An individual patient data meta-analysis of randomized controlled trials
- Abstract TMP24: Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST 2)
- Predicting Clinical Outcomes After Thrombolysis Using the iScore: Results From the Virtual International Stroke Trials Archive
- Safety of thrombolysis in stroke mimics: an observational cohort study from an urban teaching hospital in Sweden
- Comparison of Tissue Plasminogen Activator Administration Management Between Telestroke Network Hospitals and Academic Stroke Centers: The Telemedical Pilot Project for Integrative Stroke Care in Bavaria/Germany
- Outcome and Severe Hemorrhagic Complications of Intravenous Thrombolysis With Tissue Plasminogen Activator in Very Old (≥80 Years) Stroke Patients
- The impact of imbalances in baseline stroke severity on outcome in the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study.
- Abstract TMP23: Intravenous Thrombolysis in Unknown-onset Stroke