The role of mTORC1 in acne pathogenesis and treatment
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Summary
Future acne therapy should combine dietary and pharmacological interventions attenuating mTORC1 signaling by a paleolithic-type diet supported with natural or synthetic mTOR inhibitors.
- Type
- article
- Published
- 2013-12-01
- Cited by
- 6
- References
- 44
- OpenAlex
- https://openalex.org/W2094583282
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:73260189
Keywords
mTORC1, Acne, Medicine, PI3K/AKT/mTOR pathway, Pathogenesis
References
- Whey protein precipitating moderate to severe acne flares in 5 teenaged athletes.
- New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs).
- Resveratrol-Containing Gel for the Treatment of Acne Vulgaris
- Outcomes of 3% green tea emulsion on skin sebum production in male volunteers.
- The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris.
- Development of ATP-competitive mTOR Inhibitors
- Diet in acne: further evidence for the role of nutrient signalling in acne pathogenesis.
- Epidemiology of acne vulgaris
- The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial.
- EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells.
- Dietary intervention in acne
- Acne vulgaris: a disease of Western civilization.
- Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?
- Acne: risk indicator for increased body mass index and insulin resistance.
- Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds.
- Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes.
- Leucine and mTORC1: a complex relationship.
- Low serum insulin in traditional Pacific Islanders--the Kitava Study.
- Epigallocatechin-3-gallate suppresses IGF-I-induced lipogenesis and cytokine expression in SZ95 sebocytes.
- Connecting mTORC1 signaling to SREBP-1 activation
Cited by
- Linking diet to acne metabolomics, inflammation, and comedogenesis: an update
- Preliminary evidence for vitamin D deficiency in nodulocystic acne
- The P450 system and mTORC1 signalling in acne
- Milk—A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation
- La eficacia de la metformina en el tratamiento del acné moderado a severo: una revisión sistemática
- Therapeutic and Pharmaceutical Potential of Scutellaria baicalensis-Derived Exosomes for Oily Skin Disorders
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