Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses.
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Summary
The results suggest that the D1 receptor regulates the neurochemical architecture of the striatum and is critical for the normal expression of motor activity.
- Type
- article
- Published
- 1994-11-18
- Cited by
- 489
- References
- 88
- Access
- Open access
- OpenAlex
- https://openalex.org/W2094554392
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20888643
Keywords
Biology, Dopaminergic, Dopamine, Dynorphin, Neurochemical
References
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- Production and analysis of chimeric mice
- EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
- Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine
- Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes
- Dynamic regulation of NGFI-A (zif268, egr1) gene expression in the striatum
- Development of a dopamine- and cyclic adenosine 3':5'-monophosphate- regulated phosphoprotein (DARPP-32) in the prenatal rat central nervous system, and its relationship to the arrival of presumptive dopaminergic innervation
- Cocaine-induced c-fos messenger RNA is inversely related to dynorphin expression in striatum
- DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain
- Molecular neurobiology of dopaminergic receptors.
- D1-like and D2-like dopamine receptors synergistically activate rotation and c-fos expression in the dopamine-depleted striatum in a rat model of Parkinson's disease
- Dopaminergic regulation of transcription factor expression in organotypic cultures of developing striatum
- Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis
- Mesocorticolimbic dopaminergic network: functional and regulatory roles.
- Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.
- Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
- Selective Effects of Low-Dose D2 Dopamine Receptor Antagonism in a Reaction-Time Task in Rats
Cited by
- Behavioral characterization of dopamine D5 receptor null mutant mice.
- The expression of neuropeptide-induced excessive grooming behavior in dopamine D1 and D2 receptor-deficient mice.
- Les récepteurs dopaminergiques centraux : Aspects généraux (Partie I)
- Age-related behavioural phenotype and cellular characterisation of mice with progressive ablation of D1 dopamine receptor-expressing cells.
- Catecholamines in Post-Traumatic Stress Disorder
- Rotigotine Transdermal Patch Improves Swallowing in Dysphagic Patients with Parkinson’s Disease
- Behavioral analysis of multiple D1-like dopamine receptor subtypes: new agents and studies in transgenic mice with D1A receptor knockout.
- Molecular Biology Of Drug Addiction
- Dopamine in the CNS I
- The dopamine D1 receptor is a critical mediator for cocaine‐induced gene expression
- Genetic approaches to studying energy balance: perception and integration
- A measure of striatal function predicts motor stereotypy
- Functional neurochemistry of the basal ganglia.
- Cocaine effects on striatal dynorphin and CART neuropeptides : Association to mood disorder
- A mutation in CLOCK leads to altered dopamine receptor function
- Regulation of psychostimulant‐induced signaling and gene expression in the striatum
- Synthesis And Evaluation Of Novel Tropane Compounds As Potential Therapeutics For Drug Abuse
- Dopamine D1 and D3 receptors are differentially involved in cue-elicited cocaine seeking
- Sensitivity to psychostimulants in mice bred for high and low stimulation to methamphetamine
- Abnormal Synaptic Plasticity in the Striatum of Mice Lacking Dopamine D2 Receptors
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