Path toward prognostication and prediction: an evolving matrix.
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Summary
One of the greatest challenges in cancer medicine is the need to fuse prognostic and predictive markers derived from studies of groups of patients into a cohesive assessment that has relevance for an individual patient, including risks from the disease and both the risks and benefits from potential interventions.
- Type
- letter
- Published
- 2011-12-10
- Cited by
- 44
- References
- 16
- Access
- Open access
- OpenAlex
- https://openalex.org/W2092824670
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12895601
Keywords
Medicine, Psychosocial, Intervention (counseling), Population, Disease
References
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- Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer.
- Microsatellite instability in colorectal cancer—the stable evidence
- A gene expression signature of genetic instability in colon cancer.
- Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer.
- Molecular staging for survival prediction of colorectal cancer patients.
- Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin.
- Stage II colon cancer prognosis prediction by tumor gene expression profiling.
- What information should be required to support clinical "omics" publications?
- American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer.
- Validation study of a quantitative multigene reverse transcriptase-polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer.
- Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters
- Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer.
- Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer.
- Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue.
- Protocol for the Examination of Specimens from Patients with Primary Carcinoma of the Colon and Rectum Well-differentiated neuroendocrine neoplasms
Cited by
- Economic Evaluation of Potential Applications of Gene Expression Profiling in Clinical Oncology
- Unfavorable effect of small tumor size on cause-specific survival in stage IIA colon cancer, a SEER-based study
- High Expression of DARPP-32 in Colorectal Cancer Is Associated With Liver Metastases and Predicts Survival for Dukes A and B Patients: Results of a Pilot Study.
- Immunoprofiling for Prognostic Assessment of Colon Cancer: a Novel Complement to Ultrastaging
- Molecular Predictors and Prognostic Markers in the Adjuvant Therapy for Colon Cancer
- Anticipating the Clinical Use of Prognostic Gene Expression–Based Tests for Colon Cancer Stage II and III: Is Godot Finally Arriving?
- Personalizing colon cancer adjuvant therapy: selecting optimal treatments for individual patients.
- Physicians' beliefs about the benefits and risks of adjuvant therapies for stage II and stage III colorectal cancer.
- Kolonkarzinom – Neue Biologicals, neue Biomarker
- Localized colon cancer, version 3.2013: featured updates to the NCCN Guidelines.
- Association Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia Group B 9581 (Alliance).
- Nomograms to predict survival after colorectal cancer resection without preoperative therapy
- Colorectal Cancer Liver Metastasis: Evolving Paradigms and Future Directions
- Tumor size as a prognostic factor in patients with stage IIa colon cancer.
- A prognostic mutation panel for predicting cancer recurrence in stages II and III colorectal cancer
- Clinical Observation of Neoadjuvant Chemotherapy in High-Risk Stage II Colorectal Cancer: A Report of 24 Cases
- Potential biomarkers for the early diagnosis of colorectal adenocarcinoma – transcriptomic analysis of four clinical stages
- International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.
- Extent of enhancement on multiphase contrast-enhanced CT images is a potential prognostic factor of stage I–III colon cancer
- Microsatellite Instability and Adjuvant Chemotherapy in Stage II Colon Cancer
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