Differential binding of antidepressants to noradrenaline and serotonin transport sites in central nerve endings.
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Summary
Adult and 8-day old synaptosomes showed similar binding properties towards imipramine and desipraine, and tertiary amines bound more strongly than secondary amines to the serotonin carrier, as confirmed by the stronger binding of nortriptyline and chlordesipramsine compared to amitryptiline and chlorimipramines, respectively.
- Type
- article
- Published
- 1979-08-15
- Cited by
- 15
- References
- 15
- OpenAlex
- https://openalex.org/W2090186392
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4541810
Keywords
Desipramine, Imipramine, Mianserin, Chemistry, Synaptosome
References
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- Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes.
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- A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine.
- Comparative study of the effects of mianserin, a tetracyclic antidepressant, and of imipramine on uptake and release of neurotransmitters in synaptosomes
- Transport systems for GABA and for other amino acids in incubated chick brain tissue during development.
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- Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum
- Blood and brain concentrations of imipramine, clomipramine and their monomethylated metabolites after oral and intramuscular administration in rats
- The nature of (3H)imipramine binding to synaptosomes.
- Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine.
- Effect of Desmethylimipramine on the Release of [3H]Norepinephrine Induced by Various Agents in Hypothalamic Synaptosomes
Cited by
- Effects of some rigid analogues of imipramine and amitriptyline on the uptake of noradrenaline, serotonin and choline in rat brain synaptosomes.
- Clinical doses of citalopram or reboxetine differentially modulate passive and active behaviors of female Wistar rats with high or low immobility time in the forced swimming test.
- Failure of mianserin to affect autonomic function in the pupils of depressed patients
- Current concepts of the mechanisms of action of antidepressant drugs.
- Effects of mianserin on noradrenergic mechanisms.
- The tetracyclic antidepressant mianserin: evaluation of its blockade of presynaptic alpha-adrenoceptors in a self-stimulation model using clonidine.
- Paroxetin: Pharmakokinetik und Pharmakodynamik
- An examination of factors influencing adrenergic transmission in the pithed rat, with special reference to noradrenaline uptake mechanisms and post-junctional α-adrenoceptors
- 3H-noradrenaline and 3H-5-hydroxytryptamine release from rat brain slices and its presynaptic alpha-adrenergic modulation after long-term desipramine pretreatment
- Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline.
- Effects of Antidepressant Drug Treatments on α2‐Adrenoceptor Control of [3H]Noradrenaline Release from Hypothalamic Synaptosomes
- Mianserin: Pharmacological and clinical correlates
- Acute amitriptyline treatment produces non-opioid-mediated analgesia in the formalin and bee venom tests
- Effect of antidepressants on extracellular catecholamine concentrations in the rat hippocampus using in vivo microdialysis
- Primary Psychiatry: Introduction
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