Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
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Summary
It is shown that activation of the canonical Wnt pathway is sufficient to maintain self-renewal of both HESCs and MESCs, and the use of GSK-3-specific inhibitors such as BIO may have practical applications in regenerative medicine.
- Type
- article
- Published
- 2004-01-01
- Cited by
- 2,221
- References
- 48
- OpenAlex
- https://openalex.org/W2089426706
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21557803
Keywords
Wnt signaling pathway, Embryonic stem cell, Cell biology, Germ layer, Homeobox protein NANOG
References
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Cited by
- Gene Expression Profiling of Embryonic Stem Cells Leads to Greater Understanding of Pluripotency and Early Developmental Events1
- Transcriptome Profiling of Human and Murine ESCs Identifies Divergent Paths Required to Maintain the Stem Cell State
- Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity.
- Activation of Myogenic Differentiation Pathways in Adult Bone Marrow-Derived Stem Cells
- A specific and quick gene expression study in mouse ES cells
- Wnt and Frizzled RNA expression in human mesenchymal and embryonic (H7) stem cells
- Expression and function of glycogen synthase kinase-3 in human hair follicles
- EMMPRIN regulates the canonical Wnt/β-catenin signaling pathway, a potential role in accelerating lung tumorigenesis
- Integrating post‐transcriptional regulation into the embryonic stem cell gene regulatory network
- Mitotic and mitogenic Wnt signalling
- Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells.
- Induction of Pluripotent Stem Cells from Primordial Germ Cells by Single Reprogramming Factors
- miRNA let-7e Modulates the Wnt Pathway and Early Nephrogenic Markers in Mouse Embryonic Stem Cell Differentiation
- MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells
- Advances in Culture and Manipulation of Human Pluripotent Stem Cells
- IGF antagonizes the Wnt/β-Catenin pathway and promotes differentiation of extra-embryonic endoderm.
- Bronchoalveolar Sublineage Specification of Pluripotent Stem Cells: Effect of Dexamethasone Plus cAMP-Elevating Agents and Keratinocyte Growth Factor
- New insights into the conserved mechanism of pluripotency maintenance.
- Canonical and noncanonical Wnt signaling in neural stem/progenitor cells
- ESGRO-2i Medium: Inhibitor-Based Serum-free Medium for ES and iPS Cell Culture
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