Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81*
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Summary
The results indicate that lactate suppresses lipolysis in adipose tissue through a direct activation of GPR81 and may be an attractive target for the treatment of dyslipidemia and other metabolic disorders.
- Type
- article
- Published
- 2009-01-30
- Cited by
- 523
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W2086554547
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7198150
Keywords
Lipolysis, Chemistry, Receptor, Cell biology, Biochemistry
References
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- GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.
- Elucidation of signaling and functional activities of an orphan GPCR, GPR81 Published, JLR Papers in Press, January 3, 2008.
- Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35*
- Characterization of Determinants of Ligand Binding to the Nicotinic Acid Receptor GPR109A (HM74A/PUMA-G)
- Dichloroacetate inhibits glycolysis and augments insulin-stimulated glycogen synthesis in rat muscle.
- The effect of lactic acid on adipose tissue metabolism in vitro.
- Identification of Relaxin-3/INSL7 as an Endogenous Ligand for the Orphan G-protein-coupled Receptor GPCR135*
- Influence of Lactate on Isoproterenol-Induced Lipolysis and β-Adrenoceptors Distribution in Human Fat Cells
- The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids*
- Lactate inhibition of lipolysis in exercising man.
- Discovery and mapping of ten novel G protein-coupled receptor genes.
- Blood lactate and glycerol after 400-m and 3,000-m runs in sprint and long distance runners
- Mutation of Asn111 in the Third Transmembrane Domain of the AT1A Angiotensin II Receptor Induces Its Constitutive Activation*
- The Pharmacokinetics of Sodium Oxybate Oral Solution following Acute and Chronic Administration to Narcoleptic Patients
- Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
- PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
- Dichloroacetate (DCA) sensitizes both wild‐type and over expressing Bcl‐2 prostate cancer cells in vitro to radiation
Cited by
- Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes
- L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial Dysfunction via Mitohormesis
- Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response
- Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease
- Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis
- Global metabolic effect of manipulating pyruvate dehydrogenase complex activity in mammalian cells
- Regulation of Adipocyte Differentiation and Metabolism by Artificial Sweeteners and Sweet Taste Receptors.
- Structure Prediction of G-Protein Coupled Receptors
- L'application de la métabolomique à la découverte de nouveaux biomarqueurs chez les patients atteints d'acidose lactique
- Adapting brain metabolism to myelination and long‐range signal transduction
- Agonist activation of the G protein‐coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα13 and β‐arrestin‐2
- Biological and pharmacological roles of HCA receptors.
- Is lactate an undervalued functional component of fermented food products?
- Fat as a fuel: emerging understanding of the adipose tissue–skeletal muscle axis
- Cell–cell and intracellular lactate shuttles
- Screening of Different Organs of Rats for HCA2 Receptor mRNA
- L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation
- Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism
- Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain
- Synthesis and Pharmacological Properties of Silicon‐Containing GPR81 and GPR109A Agonists
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