Should there be a moratorium on the use of cholesterol lowering drugs?
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Summary
An aggressive approach to cholesterol reduction features in most of the official guidelines for the primary prevention of coronary heart disease, and high percentages of the British population would become candidates for drug treatment if the guidelines currently advanced by some authorities were put into practice.
- Type
- review
- Published
- 1992-02-15
- Cited by
- 355
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2085709114
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36216613
Keywords
Cholesterol lowering, Medicine, Pharmacology, Intensive care medicine, Cholesterol
References
- Effect of cholesterol-lowering diet on mortality from coronary heart-disease and other causes. A twelve-year clinical trial in men and women.
- An analysis of randomized trials evaluating the effect of cholesterol reduction on total mortality and coronary heart disease incidence.
- How-often-that-high graphs of serum cholesterol. Findings from the Scottish Heart Health and Scottish MONICA studies.
- Lovastatin and simvastatin prevention studies.
- A comparison of statistical methods for combining event rates from clinical trials.
- European collaborative trial of multifactorial prevention of coronary heart disease.
- Blood lipid concentrations and other cardiovascular risk factors: distribution, prevalence, and detection in Britain
- Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials.
- Lowering cholesterol concentrations and mortality
- Colestipol hydrochloride in hypercholesterolemic patients--effect on serum cholesterol and mortality.
- Cost effectiveness of incremental programmes for lowering serum cholesterol concentration: is individual intervention worth while?
- The potential and limitations of meta-analysis.
- Lowering Blood Cholesterol to Prevent Heart Disease
- A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate.
- Strategies for reducing coronary heart disease and desirable limits for blood lipid concentrations: guidelines of the British Hyperlipidaemia Association.
- The Oslo Study: diet and antismoking advice. Additional results from a 5-year primary preventive trial in middle-aged men.
- Dietary prevention of coronary heart disease: the Finnish Mental Hospital Study.
- Overview of results of randomized clinical trials in heart disease. II. Unstable angina, heart failure, primary prevention with aspirin, and risk factor modification.
- Lowering cholesterol concentrations and mortality
- Cholesterol reduction and life expectancy.
Cited by
- Mortality in participants and non-participants of a multifactorial prevention study of cardiovascular diseases: a 28 year follow up of the Helsinki Businessmen Study.
- Prospective meta-analysis of cholesterol-lowering studies: the Prospective Pravastatin Pooling (PPP) Project and the Cholesterol Treatment Trialists (CTT) Collaboration.
- Joint British recommendations on prevention of coronary heart disease in clinical practice
- The 4S Study and its Pharmacoeconomic Implications
- Management of high blood cholesterol levels in Nova Scotian adults: comparison with the NCEP II and European clinical practice guidelines.
- Conceptual foundations of the UCSD Statin Study: a randomized controlled trial assessing the impact of statins on cognition, behavior, and biochemistry.
- BASICSTATISTICS FORCLINICLkNS: 3. ASSESSINGTHE EFFECTSOF TREATMENT: MEASURESOFASSOCIATION
- Fatty acid composition of the diet: impact on serum lipids and atherosclerosis
- Anti-hyperlipidemic and antioxidant potential of different fractions of Terminalia arjuna Roxb. bark against PX- 407 induced hyperlipidemia.
- The role of statins in clinical medicine--LDL--cholesterol lowering and beyond.
- The importance of diet and physical activity in the treatment of conditions managed in general practice.
- Statin treatment should be started early
- Developing a taxonomy for research in adverse drug events: potholes and signposts
- MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.
- Meta-analysis methods for combining information from different sources in evaluating health interventions
- Changing Primary Care Doctors' Conceptions – A Qualitative Approach to Evaluating an Intervention
- Statins : The HMG CoA reductase inhibitors in perspective
- Prevention of coronary heart disease in clinical practice: recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention.
- Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors
- Hypolipidemic activity of Sesbania grandiflora in triton wr-1339 induced hyperlipidemic rats
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