Influence of chondrocyte maturation on acute response to impact injury in PEG hydrogels.
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Summary
It is confirmed that age influences how chondrocytes respond to abnormal biomechanical cues, warranting further study into the mechanisms of how cells, age, and injury contribute to the onset of osteoarthritis.
- Type
- article
- Published
- 2012-10-11
- Cited by
- 7
- References
- 52
- OpenAlex
- https://openalex.org/W2085524142
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7256208
Keywords
Anabolism, Chondrocyte, Aggrecan, Catabolism, Osteoarthritis
References
- Medium Osmolarity and Pericellular Matrix Development Improves Chondrocyte Survival When Photoencapsulated in Poly(Ethylene Glycol) Hydrogels at Low Densities
- Osteoarthritis: a disease of the joint as an organ.
- Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis.
- Early-onset osteoarthritis of mouse temporomandibular joint induced by partial discectomy
- Molecular basis of osteoarthritis: biomechanical aspects
- Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor.
- New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options
- Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age.
- Regulatory Mechanisms of Chondrogenesis and Implications for Understanding Articular Cartilage Homeostasis
- Viability and volume of in situ bovine articular chondrocytes-changes following a single impact and effects of medium osmolarity.
- OXIDANT CONDITIONING PROTECTS CARTILAGE FROM MECHANICALLY-INDUCED DAMAGE
- Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain
- Western blot quantification of aggrecan fragments in human synovial fluid indicates differences in fragment patterns between joint diseases.
- Age-related changes in the composition, the molecular stoichiometry and the stability of proteoglycan aggregates extracted from human articular cartilage.
- Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.
- Metalloproteinases, inflammation, and rheumatoid arthritis
- Transdermal photopolymerization for minimally invasive implantation.
- Influence of aging on the synthesis and morphology of the aggrecans synthesized by differentiated human articular chondrocytes.
- The role of reactive oxygen species in homeostasis and degradation of cartilage.
- The Organization of Aggrecan in Human Articular Cartilage
Cited by
- IL-10 reduces apoptosis and extracellular matrix degradation after injurious compression of mature articular cartilage.
- An overview of the role of lipid peroxidation-derived 4-hydroxynonenal in osteoarthritis
- Mitochondrial Dysfunction Is an Acute Response of Articular Chondrocytes to Mechanical Injury
- Mitochondrial dysfunction as a link between cartilage injury and osteoarthritis
- High Throughput and Mechano-Active Platforms to Promote Cartilage Regeneration and Repair
- Cell encapsulation spatially alters crosslink density of poly(ethylene glycol) hydrogels formed from free-radical polymerizations
- Bottom-up Tissue Engineering:The Effect of 3D Tissue Fabrication Strategies on Cellular Behavior.
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