Myrosinase-generated isothiocyanate from glucosinolates: isolation, characterization and in vitro antiproliferative studies.
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Summary
The isolation and characterization of ITCs derived from glucosinolates by using HPLC, GC-MS, and NMR techniques are reported and the antiproliferative activity of these compounds could be considered potentially responsible for the reduction of colorectal cancer associated with diets rich in cruciferous vegetables.
- Type
- article
- Published
- 1997-09-01
- Cited by
- 69
- References
- 14
- OpenAlex
- https://openalex.org/W2084759890
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7349432
Keywords
Glucosinolate, Myrosinase, Sinigrin, Chemistry, Isothiocyanate
References
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- A steady-state kinetics study of myrosinase with direct ultraviolet spectrophotometric assay.
- Dietary glucosinolates as blocking agents against carcinogenesis: glucosinolate breakdown products assessed by induction of quinone reductase activity in murine hepa1c1c7 cells.
- A polarographic method for the simultaneous determination of total glucosinolates and free glucose of cruciferous material.
- Interaction of proteins with allyl isothiocyanate
- Myrosinase from Sinapis alba L.: a new method of purification for glucosinolate analyses
- In Vitro Cytotoxic Activity of Some Glucosinolate-Derived Products Generated by Myrosinase Hydrolysis
- Preparation of (5R)-5-vinyloxazolidme-2-thione from natural epiprogoitrin using immobilized myrosinase
- Isolation and identification for trans-4-(methylthio)-3-butenyl glucosinolate from radish roots (Raphanus sativus L.)
- Diet and colorectal cancer: A case‐control study in Greece
- Colorectal cancer and diet in an asian population—A case‐control study among Singapore Chinese
- The thalassemia syndromes.
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- Control of soil borne potato pathogens using Brassica spp. mediated biofumigation
- Identificação de Alil Isotiocianato em crambe por HPLC
- Neuroprotective effects of Lepidium meyenii (Maca)
- The formation and antimicrobial activity of nisin and plant derived bioactive components in lactic acid bacteria fermentations
- Endogenous and exogenous enzymolysis of vegetable-sourced glucosinolates and influencing factors
- Biological Profile of Erucin: A New Promising Anticancer Agent from Cruciferous Vegetables
- Micronucleus formation and induction of apoptosis by different isothiocyanates and a mixture of isothiocyanates in human lymphocyte cultures.
- Glucosinolates, myrosinase hydrolysis products, and flavonols found in rocket (Eruca sativa and Diplotaxis tenuifolia).
- Glucosinolates fortification of cruciferous sprouts by sulphur supplementation during cultivation to enhance anti-cancer activity
- Control of brown rot on stonefruit by synthetic and glucosinolate-derived isothiocyanates
- Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes
- In vitro induction of benzo(a)pyrene cell-transforming activity by the glucosinolate gluconasturtiin found in cruciferous vegetables.
- Fungitoxic activity of four thio-functionalised glucosinolate enzyme-derived products on ten soil-borne pathogens
- Translating knowledge generated by epidemiological and in vitro studies into dietary cancer prevention.
- Nematicidal efficacy of isothiocyanates against root-knot nematode Meloidogyne javanica in cucumber
- The New Isothiocyanate 4-(Methylthio)Butylisothiocyanate Selectively Affects Cell-Cycle Progression and Apoptosis Induction of Human Leukemia Cells
- Purification of major glucosinolates from Brassicaceae seeds and preparation of isothiocyanate and amine metabolites
- Effect of storage, processing and cooking on glucosinolate content of Brassica vegetables.
- Erucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells.
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