Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
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Summary
Polychromatic flow cytometry is used to show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region that have previously been associated with two autoimmune diseases.
- Type
- article
- Published
- 2009-08-23
- Cited by
- 289
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W2080664482
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11275635
Keywords
Biology, Phenotype, Genetics, Gene, Locus (genetics)
References
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- The quantal theory of how the immune system discriminates between "self and non-self"
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- Effect of Anti‐IL‐2Rα Antibody on IL‐2‐induced Jak/STAT Signaling
- Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
- RNA-Seq: a revolutionary tool for transcriptomics
- Commonality in the genetic control of type 1 diabetes in humans and NOD mice: Variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species
- Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment.
- A Prescription for Human Immunology
- Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells.
- Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
- Progress and challenges in genome-wide association studies in humans
- The habitual, diverse and surmountable obstacles to human immunology research
- Self and Non-self
- IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production
- Purification and chemical characterization of the receptor for interleukin 2 from activated human T lymphocytes and from a human T-cell lymphoma cell line.
- Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease
- A function for interleukin 2 in Foxp3-expressing regulatory T cells
- Enhancing the Sensitivity of Assays to Detect T Cell Reactivity: The Effect of Cell Separation and Cryopreservation Media
- The IL-2/CD25 Pathway Determines Susceptibility to T1D in Humans and NOD Mice
Cited by
- IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease
- Genetics in primary sclerosing cholangitis.
- A systems genetics approach to the characterization of differential low dose radiation responses in BXD recombinant inbred mice
- Susceptibility genes for rheumatoid arthritis - a rapidly expanding harvest.
- Associations of Independent IL2RA Gene Variants with Intermediate Uveitis
- A study of the variation of leukocyte immunoglobulin-like receptors on antigen-presenting cells
- Characterisation of rare genetic variants conferring susceptibility to psoriasis
- Immunogenetics of rheumatoid arthritis: Understanding functional implications.
- DACS‐DB: AN ANNOTATION AND DISSEMINATION MODEL FOR DISEASE ASSOCIATED CYTOKINE SNPs
- Genetic basis of autoimmunity.
- T cell tolerance and the multi-functional role of IL-2R signaling in T regulatory cells
- IL‐2 promotes the function of memory‐like autoregulatory CD8+ T cells but suppresses their development via FoxP3+ Treg cells
- Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies
- Transmission disequilibrium analysis of 31 type 1 diabetes susceptibility loci in Finnish families.
- Type 1 Diabetes-associated IL2RAvariationlowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T-cell function
- Genetic architecture of early pre-inflammatory stage transcription signatures of autoimmune diabetes in the pancreatic lymph nodes of the NOD mouse reveals significant gene enrichment on chromosomes 6 and 7
- The roles of ZFAT in thymocyte differentiation and homeostasis of peripheral naive T-cells.
- Immunopathology of multiple sclerosis
- Evidence that Cd101 is an autoimmune diabetes gene in NOD mice
- The Genotype and Phenotype (GaP) registry: a living biobank for the analysis of quantitative traits
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