Radiation-induced pulmonary endothelial dysfunction in rats: modification by an inhibitor of angiotensin converting enzyme.
Explore this paper's citation graph
Summary
The ACE inhibitor Captopril ameliorates radiation-induced pulmonary endothelial dysfunction in rats sacrificed 2 months postirradiation, suggesting a novel application for this class of compounds as injury-modifying agents in irradiated lung.
- Type
- article
- Published
- 1988-07-01
- Cited by
- 101
- References
- 18
- OpenAlex
- https://openalex.org/W2080640457
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37941637
Keywords
Captopril, Medicine, Prostacyclin, Angiotensin-converting enzyme, ACE inhibitor
References
- Inhibition of vascular permeability changes in rats by captopril.
- Modification of radiation-induced pulmonary fibrosis in rats.
- Radiation injury in rat lung. IV. Modification by D-penicillamine.
- The ultrastructure of radiation injury in rat lung: modification by D-penicillamine.
- Collagen accumulation in irradiated rat lung: modification by D-penicillamine.
- Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung.
- Whither virology? Trends and prospects in medical research.
- Estimation of the plasminogen activator and the trypsin inhibitor in animal and human tissues.
- Functional responses of the pulmonary endothelium to thoracic irradiation in rats: differential modification by D-penicillamine.
- Pulmonary endothelial dysfunction induced by unilateral as compared to bilateral thoracic irradiation in rats.
- Clinical Radiation Pathology
- Radiation-induced pulmonary arterial perfusion defects: modification by D-penicillamine.
- Monocrotaline-induced cardiopulmonary injury in rats: modification by thiol and nonthiol ACE inhibitors.
- Monocrotaline-Induced Cardiopulmonary Damage in Rats: Amelioration by the Angiotensin-Converting Enzyme Inhibitor CL242817
- Monocrotaline-Induced Pulmonary Fibrosis in Rats: Amelioration by Captopril and Penicillamine
- Changes in vascular permeability following thorax irradiation in the rat.
- Prevention of pulmonary vascular changes of chronic alveolar hypoxia by inhibition of angiotensin I-converting enzyme in the rat.
- Biostatistical Analysis.
- Biostatistical analysis
- Radiation-Induced Vascular Injury and Its Relation to Late Effects in Normal Tissues
Cited by
- Serum copper concentration as an index of experimental lung injury.
- Pathogenic role of the renin-angiotensin system in modulating radiation-induced late effects.
- Sacred disease of our times: failure of the infectious disease model of spongiform encephalopathy.
- Radiopathology of the lung: experimental and clinical observations.
- Radiation pneumonitis and esophagitis in thoracic irradiation.
- Copper Bioavailability and Metabolism
- Advances in Radiation Therapy
- Angiotensin-converting enzyme inhibitors decrease the risk of radiation pneumonitis after stereotactic body radiation therapy.
- Decreasing Irradiated Rat Lung Volume Changes Dose-Limiting Toxicity From Early to Late Effects.
- Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of Radiation Proctitis?
- Impaired permeability in radiation-induced lung injury detected by technetium-99m-DTPA lung clearance.
- A quantum mechanical conformational search of 1-(3-mercaptopropionyl)-l-proline; the demethylated analogue of the potent angiotensin-converting enzyme inhibitor captopril
- Amelioration of the pathological changes induced by radiotherapy in normal tissues
- Control de síntomas crónicos. Efectos secundarios del tratamiento con Radioterapia y Quimioterapia
- Captopril reduces collagen and mast cell accumulation in irradiated rat lung.
- Radiation-induced lung injury
- ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context
- Pharmacological alteration of the lung vascular response to radiation.
- A quantum mechanical conformational search of captopril, a potent inhibitor of the angiotensin-converting enzyme
- Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme.
Related papers
- Regulation of prostacyclin generation by angiotensin converting enzyme related substances in cultured human vascular endothelial cells.
- Prostacyclin mediates the potentiated hypotensive effect of bradykinin following captopril treatment.
- Prostacyclin generation by cultured human vascular endothelial cells with reference to angiotensin I-converting enzyme.
- Effects of Angiotensin I Converting Enzyme (ACE)-Related Substances on Prostacyclin Generation and ACE Activity of Human Vascular Endothelial Cells and Rat Aortic Rings
- Differential effects of angiotensin converting enzyme inhibitors on the vasodepressor and prostacyclin responses to bradykinin.
- Angiotensin converting enzyme inhibitors, captopril and enalaprilat, augment bradykinin-induced prostacyclin synthesis in cultured rat vascular smooth muscle cells.
- Converting enzyme inhibition and vascular prostacyclin synthesis: effect of kinin receptor antagonism.
- Relationship between serum angiotensin-converting enzyme activity and plasma plasminogen activator inhibitor activity in patients with recent myocardial infarction.
- Relationship between serum angiotensin-converting enzyme activity and plasma plasminogen activator inhibitor activity in patients with recent myocardial infarction