Contribution of kinases and the CD45 phosphatase to the generation of tyrosine phosphorylation patterns in the T-cell receptor complex zeta chain.
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Summary
In vitro data suggest that the CD45 phosphatase rather than the tyrosine kinase(s) may control the generation of specific phosphorylation patterns of the zeta chain during cell activation.
- Type
- article
- Published
- 1999-04-01
- Cited by
- 18
- References
- 38
- OpenAlex
- https://openalex.org/W2079869215
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31082019
Keywords
Immunoreceptor tyrosine-based activation motif, Protein tyrosine phosphatase, SH2 domain, Phosphorylation, Tyrosine
References
- The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation.
- Phosphorylation of multiple CD3 zeta tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation.
- Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.
- Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.
- Activation of human T lymphocytes via the CD2 antigen results in tyrosine phosphorylation of T cell antigen receptor zeta-chains.
- LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
- Functional analysis of immunoreceptor tyrosinebased activation motif (ITAM)‐mediated signal transduction: the two YxxL segments within a single CD3ζITAM are functionally distinct
- Multiple kinases mediate T-cell-receptor signaling.
- Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor zeta chain.
- Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
- Regulation of antigen receptor signal transduction by protein tyrosine kinases.
- Tyrosine-phosphorylated T cell receptor zeta chain associates with the actin cytoskeleton upon activation of mature T lymphocytes.
- Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
- The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
- The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor ζ chain tyrosine‐based activation motif
- Purification and Characterization of Human ZAP-70 Protein-tyrosine Kinase from a Baculovirus Expression System*
- Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases.
- Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids.
- Antigen receptor tail clue
- Thrombin specificity. Requirement for apolar amino acids adjacent to the thrombin cleavage site of polypeptide substrate.
Cited by
- Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor zeta chain by the protein tyrosine kinase Lck.
- The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function.
- A mathematical analysis of TCR serial triggering and down‐regulation
- Comparative study on the effect of phosphorylated TCR zeta chain ITAM sequences on early activation events in Jurkat T cells.
- A protected l-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphatase inhibitors.
- Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement
- A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts.
- Negative Regulation of the NFAT1 Factor by CD45: Implication in HIV-1 Long Terminal Repeat Activation1
- Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines.
- Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45
- The life cycle of phagosomes: formation, maturation, and resolution
- CD45 in human physiology and clinical medicine.
- Molekulare Eigenschaften des Integrin-regulierenden ADAP-SKAP55-Signalkomplexes
- Membrane-anchored DNA nanojunctions enable closer antigen-presenting cell–T-cell contact in elevated T-cell receptor triggering
- Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms.
- Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Target
- Repeat Activation CD45: Implication in HIV-1 Long Terminal Negative Regulation of the NFAT1 Factor by
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