Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism.
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Summary
The results suggest that ubiquitin-dependent degradation of F-box proteins allows rapid switching among multiple SCF complexes, thereby enabling cells to adapt quickly to changing physiological conditions and progression through different phases of the cell cycle.
- Type
- article
- Published
- 1999-08-03
- Cited by
- 287
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W2079760361
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29177317
Keywords
F-box protein, Ubiquitin, Ubiquitin-conjugating enzyme, Ubiquitin-Protein Ligases, Cell division control protein 4
References
- SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
- Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins
- Activation of pp60(src) is critical for stretch-induced orienting response in fibroblasts.
- Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.
- Alpha-factor synchronization of budding yeast.
- Functional analysis of FAR1 in yeast.
- Stress resistance in Saccharomyces cerevisiae is strongly correlated with assembly of a novel type of multiubiquitin chain
- GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats
- S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase
- A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.
- Proteasome inhibitors: valuable new tools for cell biologists.
- Phosphorylation and proteolysis: partners in the regulation of cell division in budding yeast.
- The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme.
- Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis.
- SCF and APC: the Yin and Yang of cell cycle regulated proteolysis.
- Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein
- Guide to yeast genetics and molecular biology
- F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
- Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases.
- The Cdc42p effector Gic2p is targeted for ubiquitin‐dependent degradation by the SCFGrr1 complex
Cited by
- Interaction of the virulence protein VirF of Agrobacterium tumefaciens with plant homologs of the yeast Skp1 protein.
- The Gap Junction-independent Tumor-suppressing Effect of Connexin 43*
- Roles of SCF and VHL ubiquitin ligases in regulation of cell growth.
- CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70
- N-Terminal Hemagglutinin Tag Renders Lysine-Deficient APOBEC3G Resistant to HIV-1 Vif-Induced Degradation by Reduced Polyubiquitination
- Post transcriptional regulation of cyclin E during the embryonic development of Xenopus laevis
- Regulators of Ubiquitin Dependent Protein Degradation in the Filamentous Fungus Aspergillus nidulans : Insights into CsnB, DenA and CandA Function
- Natural substrates of the proteasome and their recognition by the ubiquitin system.
- Structural Insights into Substrate Binding and Regulation of E3 Ubiquitin Ligases in the Nedd4 Family using NMR Spectroscopy
- Mechanisms of human papillomavirus type 16 E7 (HPV-16 E7)-induced disruption of centriole duplication control
- Cellular control of ubiquitin-proteasome-dependent proteolysis
- COP9 signalosome subunit knockdown in K562 provides novel insight into the function and potential regulation of the CSN
- THE NOVEL UPSTREAM REGULATOR OF FBXW7
- Investigation of the FAT10 conjugation pathway
- ANALYSIS OF ELECTROPHILE-INDUCED NRF2 GENE ACTIVATION
- Systems analysis of robustness in cellular networks
- Dissecting roles and regulation of the fission yeast kinetochore protein Spc7
- COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases.
- F-box proteins and protein degradation: An emerging theme in cellular regulation
- Lysine11-Linked Polyubiquitination of the AnkB F-Box Effector of Legionella pneumophila
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