Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

Keywords

IDH2, Phenotype, IDH1, Haematopoiesis, Biology

References

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Cited by

• JAK2V617F-positive Myeloproliferative Neoplasms : KI mouse models, Interferon-α therapy and clonal architectureSalma Hasan — 2013
• Impact of molecular prognostic factors in cytogenetically normal acute myeloid leukemia at diagnosis and relapse守 和田 — 2011
• Roles of the hypoxia response system in hematopoietic and leukemic stem cellsFelicty Duncan — 2012
• Mutation Patterns of 16 Genes in Primary and Secondary Acute Myeloid Leukemia (AML) with Normal CytogeneticsLucy Ferguson — 2012
• IDH1 mutations disrupt blood, brain, and barriers.Thierry Karsenti, Gilles Thibert — 2012
• Metabolic Plasticity and Hematopoietic Stem Cell BiologyJeanne Dion — 2013
• Stem cell metabolism in tissue development and agingЗедгенизов Дмитрий Владиленович — 2013
• Lessons from next-generation sequencing analysis in hematological malignanciesMohamed Chafiq — 2013
• Hypoxia and metabolism in cancer.Priya Gothwal, Ila Shukla — 2014
• Oncometabolites‐driven tumorigenesis: From genetics to targeted therapyВоробьева Алла Викторовна — 2014
• Effects of deranged metabolism on epigenetic changes in cancerThomas H. Lee — 2015
• New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma直也 片山, 秀成 髙 — 2015
• Protein species and moonlighting proteins: Very small changes in a protein's covalent structure can change its biochemical function.知良 井出, 晃彦 中江, 重幸 阿満 — 2016
• The Impact of DNA Methylation in Hematopoietic MalignanciesM.Ikom Ir. Dwi Atmono Agus Widodo — 2016
• Translational and clinical implications of the genetic landscape of prostate cancerGrégory Segala — 2016
• Metformin targets histone acetylation in cancer-prone epithelial cells芳秀 添谷 — 2016
• Novel Therapies for Acute Myeloid Leukemia: Are We Finally Breaking the Deadlock?Альбина Сагателовна Евсеева — 2017
• Glioma biology and molecular markers.Adam L. Cohen, Howard Colman — 2015
• Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. A study by the French ALFA groupJonathan D. Jansen — 2018
• Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic targetCarlos G. Lopez — 2018

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