Treatment of early chronic lymphocytic leukemia: Intermittent chlorambucil versus observation
Explore this paper's citation graph
Summary
Early treatment of CLL with intermittent chlorambucil did not result in a survival advantage for patients with indolent stage I and II CLL at 5 years from randomization.
- Type
- article
- Published
- 1988-01-01
- Cited by
- 117
- References
- 17
- OpenAlex
- https://openalex.org/W2078249396
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30684436
Keywords
Chlorambucil, Chronic lymphocytic leukemia, Medicine, Randomization, Stage (stratigraphy)
References
- Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia.
- A clinical staging system for chronic lymphocytic leukemia. Prognostic significance
- Does therapy alter the natural history and prognosis of chronic lymphocytic leukemia?
- The treatment of chronic lymphocytic leukemia with COP chemotherapy
- Guidelines for protocol studies in chronic lymphocytic leukemia
- Combination chemotherapy of advanced chronic lymphocytic leukemia: the M-2 protocol (vincristine, BCNU, cyclophosphamide, melphalan, and prednisone).
- Studies of leukocyte kinetics in chronic lymphocytic leukemia.
- [Treatment of chronic lymphocytic leukemia].
- Clinical staging of chronic lymphocytic leukemia.
- Prognostic factors in chronic lymphocytic leukaemia and their implications for therapy.
- Statistical methods for rates and proportions
- Combination Chemotherapy
- HPR63 Estimates of the Global Burden of COVID-19 and the Value of Broad and Equitable Access to COVID-19 Vaccines
- Statistical Methods for Rates and Proportions.
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Cited by
- T-small cell disorders
- Progress in the treatment of chronic lymphocytic leukemia: results of the German CLL8 trial
- National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment.
- Immunologie de la polypose nasosinusienne
- Expression et fonctionnalité des Toll-Like récepteurs par les cellules de leucémie lymphoïde chronique B
- Chronic lymphocytic leukemia: new insights into the tumor microenvironment and sensitivity to rationally selected compounds
- Clinical prognostic markers in chronic lymphocytic leukemia
- Immunological and molecular studies for the development of vaccine therapy for chronic lymphocytic leukemia
- Targeted monoclonal antibody therapy in chronic lymphocytic leukemia
- T Cells in Patients with B-cell Chronic Lymphocytic Leukemia (B-CLL) and Multiple Myeloma (MM) An Immunological Study
- Chronic Lymphocytic Leukemia
- New modalities of therapy in chronic lymphocytic leukemia.
- Management of Chronic Lymphocytic Leukaemia
- Current Treatment for Chronic Lymphocytic Leukemia
- Clinical heterogeneity reflects biologic diversity in chronic lymphocytic leukemia.
- Alkylating agents and nucleoside analogues in the treatment of B cell chronic lymphocytic leukemia
- Initial therapy for patients with chronic lymphocytic leukemia.
- Chemotherapy of chronic haematological malignancies.
- Chronic lymphocytic leukemia: when to start treatment
- Interferon‐alpha 2b (IFNα) for Early‐Phase Chronic Lymphocytic Leukaemia with High Risk for Disease Progression: Results of a Randomized Multicentre Study
Related papers
- Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia.
- Chlorambucil and fludarabine as a new pre-transplant conditioning for patients with chronic lymphocytic leukemia: results of in vivo experiments
- Concomitant administration of chlorambucil limits dose intensity of fludarabine in previously treated patients with chronic lymphocytic leukemia.
- Fludarabine versus chlorambucil: is the debate over?
- The Lack of Survival Differences in Randomised Trials in CLL May Be Related to the Effect of Second Line Therapies. A Report from the LRF CLL4 Trial.
- First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia.
- Combination therapies for previously untreated CLL.