Transdifferentiation of hepatocyte‐like cells from the human hepatoma HepaRG cell line through bipotent progenitor
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Summary
The results demonstrate the great plasticity of transformed hepatic progenitor cells and suggest that the transdifferentiation process could supply the pool of hepaticprogenitor cells, and highlight possible mechanisms by which trans Differentiation and proliferation of unipotent hepatocytes might cooperate in the development of mixed and differentiated tumors.
- Type
- article
- Published
- 2007-04-01
- Cited by
- 374
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2077692978
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10523218
Keywords
Transdifferentiation, Progenitor cell, Cell biology, Hepatocyte, Biology
References
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Cited by
- Stratégie de vectorisation d'acides nucléiques et de drogues anticancéreuses dans les cellules hépatiques en culture
- Translational control plays a prominent role in the hepatocytic differentiation of HepaRG liver progenitor cells
- Intermediate hepatobiliary cells predict an increased risk of hepatocarcinogenesis in patients with hepatitis C virus-related cirrhosis.
- Multiparametric assay using HepaRG cells for predicting drug-induced liver injury.
- Toward Preclinical Predictive Drug Testing for Metabolism and Hepatotoxicity by Using In Vitro Models Derived from Human Embryonic Stem Cells and Human Cell Lines — A Report on the Vitrocellomics EU-project
- Scaling-up of a HepaRG progenitor cell based bioartificial liver: optimization for clinical application and transport
- Cell-printed 3D liver-on-a-chip possessing a liver microenvironment and biliary system
- The application of HepRG cells in evaluation of cytochrome P450 induction properties of drug compounds.
- The HepaRG cell line: biological properties and relevance as a tool for cell biology, drug metabolism, and virology studies.
- General review on in vitro hepatocyte models and their applications.
- Characterization of Flavin-containing Monooxygenase-3 (FMO3) as a Novel Genetic Determinant of Acetaminophen (APAP) Induced Hepatotoxicity
- Toxicogenomics responses in the in vitro liver : a view on human interindividual variation
- Rôle de la protéine Gas6 et des cellules précurseurs dans la stéatohépatite et la fibrose hépatique
- Effets d’un mélange de polluants organiques persistants sur le métabolisme hépatique
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