Underrepresentation of Elderly People in Randomised Controlled Trials. The Example of Trials of 4 Widely Prescribed Drugs
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Summary
Elderly patients are poorly represented in RCTs of drugs they are likely to receive, with the proportion of patients aged 65 or older lower than half that in the treated population.
- Type
- article
- Published
- 2012-03-30
- Cited by
- 152
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2077180817
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8422386
Keywords
Medicine, Pioglitazone, Valsartan, Randomized controlled trial, Population
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Cited by
- The burden of disease in older people and implications for health policy and practice.
- Characteristics of Randomized Controlled Trials Designed for Elderly: A Systematic Review
- From statin efficacy to everyday effectiveness: Studying the gap in between.
- Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects
- Coxibs and traditional NSAIDs for pain relief.
- Systematic Review: Representativeness of Participants in RCTs of Acetylcholinesterase Inhibitors
- Application of the STOPP/START criteria: a systematic review of the prevalence of potentially inappropriate prescribing in older adults, and evidence of clinical, humanistic and economic impact
- Attitudes of Older Adults to Their Participation in Clinical Trials: A Pilot Study
- Comparison of Treatment Effect Estimates for Pharmacological Randomized Controlled Trials Enrolling Older Adults Only and Those including Adults: A Meta-Epidemiological Study
- Exclusion of Older Adults from Ongoing Clinical Trials About Type 2 Diabetes Mellitus
- The influence of ageing on the development and management of rheumatoid arthritis
- A Standardized Bleeding Risk Score Aligns Anticoagulation Choices with Current Evidence
- Participation of Older People in Preauthorization Trials of Recently Approved Medicines
- Analgesic drug consumption increases after knee arthroplasty: A pharmacoepidemiological study investigating postoperative pain
- Medication non-compliance in older patients: a multifactorial problem.
- Linear and Curvilinear Relationship between Knee Range of Motion and Physical Functioning in People with Knee Osteoarthritis: A Cross-Sectional Study
- How good is "evidence" from clinical studies of drug effects and why might such evidence fail in the prediction of the clinical utility of drugs?
- Public mental health research in Europe: a systematic mapping for the ROAMER project.
- Platelet function monitoring in elderly patients on prasugrel after stenting for an acute coronary syndrome: design of the randomized antarctic study.
- Statin use and clinical outcomes in older men: a prospective population-based study
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