Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms
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Summary
This review highlights the clinical significance of chromosomally encoded AmpC cephalosporinase, the outer membrane porin OprD, and the multidrug efflux pumps, as well as the complex mechanisms/pathways by which P. aeruginosa regulates their expression.
- Type
- review
- Published
- 2009-10-01
- Cited by
- 1,877
- References
- 311
- Access
- Open access
- OpenAlex
- https://openalex.org/W2075287054
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206738058
Keywords
Pseudomonas aeruginosa, Efflux, Biology, Porin, Microbiology
References
- DNA sequence differences of ampD mutants of Citrobacter freundii
- Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa
- Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region
- An ampD Gene in Pseudomonas aeruginosa Encodes a Negative Regulator of AmpC β-Lactamase Expression
- Genetic basis for dissemination of armA.
- Benefit of Having Multiple ampD Genes for Acquiring β-Lactam Resistance without Losing Fitness and Virulence in Pseudomonas aeruginosa
- Impact of AmpC overexpression on outcomes of patients with Pseudomonas aeruginosa bacteremia.
- Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions.
- Affinity purification and binding characteristics of Citrobacter freundii AmpR, the transcriptional regulator of the ampC beta‐lactamase gene
- Inducible cephalosporinase production in clinical isolates of Enterobacter cloacae is controlled by a regulatory gene that has been deleted from Escherichia coli.
- Binding of the Citrobacter freundii AmpR regulator to a single DNA site provides both autoregulation and activation of the inducible ampC beta-lactamase gene
- Location of N-acetylmuramyl-L-alanyl-D-glutamylmesodiaminopimelic acid, presumed signal molecule for beta-lactamase induction, in the bacterial cell
- Contribution of extended-spectrum AmpC (ESAC) beta-lactamases to carbapenem resistance in Escherichia coli.
- Multidrug efflux pumps of gram-negative bacteria
- Expression in Escherichia coli of a New Multidrug Efflux Pump, MexXY, from Pseudomonas aeruginosa
- Protein D2 channel of the Pseudomonas aeruginosa outer membrane has a binding site for basic amino acids and peptides.
- Bacterial cell wall recycling provides cytosolic muropeptides as effectors for beta‐lactamase induction.
- Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase.
- Cefepime: the next generation?
- Emerging carbapenemases in Gram-negative aerobes.
Cited by
- Isolation And Characterization Of Natural Antimicrobials From Plant And Marine Organisms
- In vivo development of antimicrobial resistance in Pseudomonas aeruginosa strains isolated from the lower respiratory tract of Intensive Care Unit patients with nosocomial pneumonia and receiving antipseudomonal therapy.
- The Regulatory Repertoire of Pseudomonas aeruginosa AmpC ß-Lactamase Regulator AmpR Includes Virulence Genes
- Expression of ampC, oprD, and mexA, outer membrane protein analysis and carbapenemases in multidrug resistant clinical isolates of Pseudomonas aeruginosa from Egypt
- Cell-surface signaling in Pseudomonas: stress responses, iron transport, and pathogenicity.
- Efflux pump regulatory genes mutations in multidrug resistance Pseudomonas aeruginosa isolated from wound infections in Isfahan hospitals
- Sputum containing zinc enhances carbapenem resistance, biofilm formation and virulence of Pseudomonas aeruginosa.
- Genomic Insights into Intrinsic and Acquired Drug Resistance Mechanisms in Achromobacter xylosoxidans
- Overexpression of MexAB-OprM efflux pump in carbapenem-resistant Pseudomonas aeruginosa
- Evidence for Direct Control of Virulence and Defense Gene Circuits by the Pseudomonas aeruginosa Quorum Sensing Regulator, MvfR
- CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa
- Ceftolozane-Tazobactam Activity against Pseudomonas aeruginosa Clinical Isolates from U.S. Hospitals: Report from the PACTS Antimicrobial Surveillance Program, 2012 to 2015
- Phages & antibiotic resistance: are the most abundant entities on earth ready for a comeback?
- Studies on enhanced surface disinfection and skin antisepsis using chlorhexidine and eucalyptus oil
- Etudes structurale et fonctionnelle de protéines impliquées dans la virulence chez S. pneumoniae et P. aeruginosa
- Cambios en la fisiología de Pseudomonas aeruginosa causados por la sobre-expresión del sistema múltiple de bombeo MexEF-OprN
- Detección de sistemas de expulsión involucrados en la resistencia a antibióticos en aislamientos clínicos de Pseudomonas aeruginosa
- Establishing PCR for the detection of Pseudomonas aeruginosa from keratitis patients
- Regulation of virulence gene expression by Rsm homologs in Pseudomonas aeruginosa
- 2007 Astellas USA Foundation Award: Host-Guest Chemistry of the Peptidoglycan
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